DegronMD

Uniprot ID: Q8TBC5

Source protein: Zinc finger and SCAN domain-containing protein 18

Source gene: ZSCAN18

Class: DEG_SCF_FBW7_1

Location: 181:188

E3 ligase: FBXW7

DEGRON score: 0.951

ASA_SCORE: 84.7875

COIL: 0.8918

CONS_SCORE: 0.4937

DSS_SCORE: 0.6156

HELIX: 0.0758

FCONS_SCORE: 1.0539

RIG_SCORE: 0.6699

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L187P	TCGA-21-1077	LUSC	TCGA	PSETPWLS	DEG_SCF_FBW7_1	0.6471
p.L187P	DO26725	LUSC	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.6471
p.A184T	TCGA-B5-A3FC	UCEC	TCGA	PSETPWLS	DEG_SCF_FBW7_1	0.7139
p.A184T	DO41871	UCEC	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.7139
p.A184T	SIDM01113	Other Sarcomas	GDSC	PSETPWLS	DEG_SCF_FBW7_1	0.7139
p.A184T	ACH-000939	Sarcoma	CCLE	PSETPWLS	DEG_SCF_FBW7_1	0.7139
p.A184T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	0.7139
p.A184T	SK-UT-1	soft_tissue	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.7139
p.A198V	TCGA-B7-5816	STAD	TCGA	PSETPWLS	DEG_SCF_FBW7_1	0.0556
p.A198V	TCGA-D7-A6EY	STAD	TCGA	PSETPWLS	DEG_SCF_FBW7_1	0.0556
p.A198V	TCGA-OR-A5J5	ACC	TCGA	PSETPWLS	DEG_SCF_FBW7_1	0.0556
p.A176T	TCGA-DK-AA6L	BLCA	TCGA	PSETPWLS	DEG_SCF_FBW7_1	0.1944
p.A176T	DO219002	BLCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.1944
p.A177T	DO230311	COCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.2222
p.A177T	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	PSETPWLS	DEG_SCF_FBW7_1	0.2222
p.A177T	ACH-000787	Lung Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	0.2222
p.A177T	LXF-289	lung	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.2222
p.S183L	DO234402	ESAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.7667
p.G184A	DO25242	LUAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.754
p.G176V	DO26052	LUAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.1944
p.E188K	DO220878	MELA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.7022
p.E188K	DO229453	SKCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.7022
p.P193S	DO222453	MELA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.1944
p.D198N	DO229453	SKCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.0556
p.G175W	DO37746	SKCM	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.1667
p.P193L	DO223907	SKCM	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.1944
p.P193L	OE19	oesophagus	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.1944
p.P173T	DO47925	STAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.1111
p.A179S	DO229140	THCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	0.2778
p.C173Y	SIDM00220	Ovarian Carcinoma	GDSC	PSETPWLS	DEG_SCF_FBW7_1	0.1111
p.C173Y	ACH-000962	Ovarian Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	0.1111
p.C173Y	ACH-001145	Ovarian Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	0.1111
p.C173Y	OC-314	ovary	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.1111
p.P179L	RCC-FG2	kidney	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.2778
p.L173F	TGW	autonomic_ganglia	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.1111
p.A180T	SNU-407	large_intestine	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.3056
p.P181H	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.7694
p.D176G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSETPWLS

Degron related mutations and impact score

Drug responses associated with ZSCAN18 mutations

All proteins holding degron of PSETPWLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBC5	Zinc finger and SCAN domain-containing protein 18	DEG_SCF_FBW7_1	181:188	PSETPWLS	FBXW7	0.951	More...