DegronMD - Q71F56(MED13L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1519I	TCGA-06-5416	GBM	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1389
p.L1519I	DO10880	GBM	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1389
p.D802N	TCGA-06-5416	GBM	TCGA	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation rewiring degron network	0.1667
p.D802N	DO10880	GBM	ICGC	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation rewiring degron network	0.1667
p.P2013L	TCGA-13-0887	OV	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.0833
p.P2013L	DO31969	OV	ICGC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.0833
p.S457L	TCGA-3N-A9WD	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7667
p.S457L	DO51235	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7667
p.E404K	TCGA-49-AARE	LUAD	TCGA	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.2778
p.E404K	DO218922	LUAD	ICGC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.2778
p.P1594L	TCGA-50-5941	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.P1594L	DO25528	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.N2011I	TCGA-60-2698	LUSC	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.1389
p.N2011I	DO26469	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.1389
p.T1516S	TCGA-67-3774	LUAD	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.0556
p.T1516S	DO24990	LUAD	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.0556
p.R1045L	TCGA-85-A4CL	LUSC	TCGA	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.7316
p.R1045L	DO45454	LUSC	ICGC	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.7316
p.S2003L	TCGA-A1-A0SH	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation altering degron motif	0.7667
p.S2003L	DO1261	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation altering degron motif	0.7667
p.A1083T	TCGA-A5-A0G2	UCEC	TCGA	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.6028
p.A1083T	DO41235	UCEC	ICGC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.6028
p.P405S	TCGA-A8-A07E	BRCA	TCGA	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.25
p.P405S	DO5368	BRCA	ICGC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.25
p.S160I	TCGA-AA-3815	COAD	TCGA	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S160I	DO9924	COAD	ICGC	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.D1520Y	TCGA-AC-A23H	BRCA	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1667
p.D1520Y	TCGA-BF-A1PZ	SKCM	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1667
p.D1520Y	DO2401	BRCA	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1667
p.D1520Y	DO50279	SKCM	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1667
p.A792T	TCGA-AP-A0LM	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation altering degron motif	0.7139
p.A792T	DO43306	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation altering degron motif	0.7139
p.R388I	TCGA-AX-A05Z	UCEC	TCGA	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.1111
p.R388I	DO40884	UCEC	ICGC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.1111
p.A1042T	TCGA-AX-A3FS	UCEC	TCGA	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.6028
p.A1042T	TCGA-PG-A917	UCEC	TCGA	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.6028
p.A1042T	DO40879	UCEC	ICGC	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.6028
p.A1042T	DO52424	UCEC	ICGC	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.6028
p.S1589L	TCGA-B5-A0JY	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation altering degron motif	0.7667
p.S1589L	DO43041	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation altering degron motif	0.7667
p.Q1537H	TCGA-B5-A1MX	UCEC	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1111
p.Q1537H	DO41999	UCEC	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.1111
p.P1533A	TCGA-BR-4361	STAD	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.2222
p.P1533A	DO38887	STAD	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.2222
p.D1078N	TCGA-BS-A0UV	UCEC	TCGA	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.2222
p.D1078N	DO232761	PBCA	ICGC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.2222
p.D1078N	DO42793	UCEC	ICGC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.2222
p.D1078N	ACH-001132	Lymphoma	CCLE	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.2222
p.N770K	TCGA-CA-6717	COAD	TCGA	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1111
p.N770K	DO8264	COAD	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1111
p.H1995R	TCGA-CG-5723	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.1944
p.H1995R	DO38376	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.1944
p.I1525V	TCGA-CK-5913	COAD	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.3056
p.I1525V	TCGA-D1-A103	UCEC	TCGA	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.3056
p.I1525V	DO8826	COAD	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.3056
p.I1525V	DO35442	PACA	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.3056
p.I1525V	DO42312	UCEC	ICGC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.3056
p.I1996V	TCGA-CV-7180	HNSC	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.2222
p.I1996V	DO14742	HNSC	ICGC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.2222
p.S2063F	TCGA-CV-7568	HNSC	TCGA	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation rewiring degron network	0.2222
p.S2063F	DO14160	HNSC	ICGC	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation rewiring degron network	0.2222
p.D749G	TCGA-D1-A103	UCEC	TCGA	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1389
p.D749G	DO42312	UCEC	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1389
p.P1057Q	TCGA-D3-A2J6	SKCM	TCGA	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation rewiring degron network	0.0556
p.P1057Q	DO37901	SKCM	ICGC	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation rewiring degron network	0.0556
p.S1570F	TCGA-D8-A73U	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1570F	DO219629	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.D755G	TCGA-DD-AAVY	LIHC	TCGA	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.3056
p.D755G	DO52284	LIHC	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.3056
p.Q1598H	TCGA-DU-6392	LGG	TCGA	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.1111
p.Q1598H	DO22237	LGG	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.1111
p.G760D	TCGA-DU-6392	LGG	TCGA	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.6087
p.G760D	DO22237	LGG	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.6087
p.P318Q	TCGA-EB-A24C	SKCM	TCGA	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1944
p.P318Q	DO37438	SKCM	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1944
p.G750V	TCGA-EK-A2RM	CESC	TCGA	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1667
p.G750V	DO49956	CESC	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1667
p.S1566L	TCGA-EO-A22U	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.1111
p.S1566L	TCGA-FD-A6TE	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.1111
p.S1566L	DO49759	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.1111
p.S1566L	DO43755	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.1111
p.H172N	TCGA-EO-A22X	UCEC	TCGA	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7423
p.H172N	DO43907	UCEC	ICGC	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7423
p.P1086L	TCGA-FS-A1ZF	SKCM	TCGA	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7582
p.P1086L	DO38039	SKCM	ICGC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7582
p.I1596V	TCGA-HD-7753	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.1667
p.I1596V	DO14614	HNSC	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.1667
p.N1093S	TCGA-HU-A4H3	STAD	TCGA	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.2222
p.N1093S	DO47903	STAD	ICGC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.2222
p.I2005V	TCGA-LN-A49R	ESCA	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.3056
p.D1990Y	TCGA-ND-A4WC	UCS	TCGA	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.0556
p.R791I	TCGA-NJ-A4YQ	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation rewiring degron network	0.3056
p.R791I	DO218944	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation rewiring degron network	0.3056
p.D317Y	TCGA-VQ-AA6I	STAD	TCGA	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1667
p.D317Y	DO222398	STAD	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.1667
p.P331S	TCGA-W3-AA1V	SKCM	TCGA	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.3056
p.P331S	DO51276	SKCM	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.3056
p.P331S	SIDM00948	Burkitt's Lymphoma	GDSC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.3056
p.P331S	ACH-002232	Lymphoma	CCLE	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.3056
p.P331S	DG-75	haematopoietic and lymphoid tissue	COSMIC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.3056
p.E402Q	TCGA-ZF-AA51	BLCA	TCGA	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation altering degron motif	0.6744
p.E402Q	DO219093	BLCA	ICGC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation altering degron motif	0.6744
p.R1045P	DO221456	AML	ICGC	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.6401
p.R1045H	DO233634	GACA	ICGC	PATPRFS	DEG_SCF_FBW7_1	1041:1047	Mutation altering degron motif	0.7133
p.S1600N	DO11854	GBM	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.0556
p.T763K	DO228986	LICA	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation blocking phosphorylation signal	0.75
p.A410D	DO229028	LICA	ICGC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.1111
p.A1593D	DO229022	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.25
p.A184D	DO229032	LICA	ICGC	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0556
p.S1583Y	DO229031	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.1944
p.S1583Y	DO229031	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.25
p.T798K	DO229031	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	792:796	Mutation rewiring degron network	0.2778
p.P2055Q	DO229035	LICA	ICGC	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation altering degron motif	0.5924
p.S762Y	DO229045	LICA	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.8231
p.P461H	DO229050	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2222
p.T2044S	DO229052	LICA	ICGC	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation rewiring degron network	0.1944
p.G750R	DO50846	LICA	ICGC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation rewiring degron network	0.1667
p.G2040S	DO231102	LUSC	ICGC	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation rewiring degron network	0.0833
p.P2062L	DO219878	SKCA	ICGC	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation rewiring degron network	0.25
p.L1092F	DO229462	SKCA	ICGC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.25
p.S339R	DO229465	SKCA	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.0833
p.I1996T	DO229211	THCA	ICGC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00454	Rhabdomyosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00454	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00200	Ewing's Sarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00200	Ewing's Sarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00971	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00971	Breast Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00808	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM00808	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.S1582T	SIDM01254	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.S1582T	SIDM01254	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.2222
p.P759S	SIDM00572	Gastric Carcinoma	GDSC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.6752
p.P759S	ACH-000911	Gastric Cancer	CCLE	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.6752
p.P759S	NUGC-3	stomach	COSMIC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.6752
p.F449C	SIDM00465	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2222
p.F449C	ACH-002183	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2222
p.F449C	OVMIU	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2222
p.V1072I	SIDM00284	Melanoma	GDSC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.0556
p.M323I	SIDM00285	Neuroblastoma	GDSC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation altering degron motif	0.6507
p.M323I	CHP-134	autonomic ganglia	COSMIC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation altering degron motif	0.6507
p.S391P	SIDM01088	Endometrial Carcinoma	GDSC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation blocking phosphorylation signal	0.6389
p.S391P	ACH-000965	Endometrial/Uterine Cancer	CCLE	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation blocking phosphorylation signal	0.6389
p.S391P	RL95-2	endometrium	COSMIC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation blocking phosphorylation signal	0.6389
p.T2004A	SIDM00217	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation altering degron motif	0.7139
p.T2004A	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation altering degron motif	0.7139
p.T2004A	SNU-1040	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	2000:2004	Mutation altering degron motif	0.7139
p.A1591T	SIDM00217	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.3056
p.A1591T	ACH-000999	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.3056
p.A1591T	SNU-1040	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	1586:1590	Mutation rewiring degron network	0.3056
p.S1076N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1667
p.S1076N	ACH-001127	Leukemia	CCLE	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1667
p.S1076N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1667
p.N387S	SIDM00213	Thyroid Gland Carcinoma	GDSC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.0833
p.N387S	SIDM00228	Thyroid Gland Carcinoma	GDSC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.0833
p.N387S	ACH-000897	Thyroid Cancer	CCLE	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.0833
p.N387S	ACH-000903	Thyroid Cancer	CCLE	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.0833
p.N387S	FTC-133	thyroid	COSMIC	MSTPTLE	DEG_SCF_FBW7_2	396:402	Mutation rewiring degron network	0.0833
p.T758I	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.8189
p.T758I	ACH-000869	Lung Cancer	CCLE	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.8189
p.T758I	NCI-H1568	lung	COSMIC	VTTPGHS	DEG_SCF_FBW7_1	756:762	Mutation altering degron motif	0.8189
p.S314N	SIDM01640	Acute Myeloid Leukemia	GDSC	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.0833
p.S314N	ACH-000602	Leukemia	CCLE	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.0833
p.A184V	SIDM01588	Endometrial Carcinoma	GDSC	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0556
p.A184V	ACH-000993	Endometrial/Uterine Cancer	CCLE	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0556
p.G1538E	SIDM01525	Acute Myeloid Leukemia	GDSC	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.0833
p.G1538E	ACH-000557	Leukemia	CCLE	PPKY	ITCH	1526:1529	Mutation rewiring degron network	0.0833
p.S1570T	ACH-000296	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2222
p.C321R	ACH-000974	Endometrial/Uterine Cancer	CCLE	MPLTPPTS	DEG_SCF_FBW7_1	323:330	Mutation rewiring degron network	0.2778
p.S2049P	ACH-000999	Colon/Colorectal Cancer	CCLE	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation altering degron motif	0.6752
p.S2049P	SNU-1040	large intestine	COSMIC	SSPNSSPVPSP	DEG_COP1_1	2049:2059	Mutation altering degron motif	0.6752
p.K159T	ACH-001645	Skin Cancer	CCLE	FFLHGE	LIG_APCC_ABBA_1	169:174	Mutation substituting flanking lysine	0.1667
p.T1085P	DB	haematopoietic and lymphoid tissue	COSMIC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7031
p.T1085P	SCC90	upper aerodigestive tract	COSMIC	PASTPSTT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED13L

UniProt ID: Q71F56

Entrez ID: 23389

Protein name: Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED13L in