DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: DEG_SCF_FBW7_2

Location: 396:402

E3 ligase: FBXW7

DEGRON score: 0.6569

ASA_SCORE: 93.7714

COIL: 0.8284

CONS_SCORE: 0.2434

DSS_SCORE: 0.6638

HELIX: 0.1584

FCONS_SCORE: 0.9227

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E404K	TCGA-49-AARE	LUAD	TCGA	MSTPTLE	DEG_SCF_FBW7_2	0.2778
p.E404K	DO218922	LUAD	ICGC	MSTPTLE	DEG_SCF_FBW7_2	0.2778
p.P405S	TCGA-A8-A07E	BRCA	TCGA	MSTPTLE	DEG_SCF_FBW7_2	0.25
p.P405S	DO5368	BRCA	ICGC	MSTPTLE	DEG_SCF_FBW7_2	0.25
p.R388I	TCGA-AX-A05Z	UCEC	TCGA	MSTPTLE	DEG_SCF_FBW7_2	0.1111
p.R388I	DO40884	UCEC	ICGC	MSTPTLE	DEG_SCF_FBW7_2	0.1111
p.E402Q	TCGA-ZF-AA51	BLCA	TCGA	MSTPTLE	DEG_SCF_FBW7_2	0.6744
p.E402Q	DO219093	BLCA	ICGC	MSTPTLE	DEG_SCF_FBW7_2	0.6744
p.A410D	DO229028	LICA	ICGC	MSTPTLE	DEG_SCF_FBW7_2	0.1111
p.S391P	SIDM01088	Endometrial Carcinoma	GDSC	MSTPTLE	DEG_SCF_FBW7_2	0.6389
p.S391P	ACH-000965	Endometrial/Uterine Cancer	CCLE	MSTPTLE	DEG_SCF_FBW7_2	0.6389
p.S391P	RL95-2	endometrium	COSMIC	MSTPTLE	DEG_SCF_FBW7_2	0.6389
p.N387S	SIDM00213	Thyroid Gland Carcinoma	GDSC	MSTPTLE	DEG_SCF_FBW7_2	0.0833
p.N387S	SIDM00228	Thyroid Gland Carcinoma	GDSC	MSTPTLE	DEG_SCF_FBW7_2	0.0833
p.N387S	ACH-000897	Thyroid Cancer	CCLE	MSTPTLE	DEG_SCF_FBW7_2	0.0833
p.N387S	ACH-000903	Thyroid Cancer	CCLE	MSTPTLE	DEG_SCF_FBW7_2	0.0833
p.N387S	FTC-133	thyroid	COSMIC	MSTPTLE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SCF_FBW7_2	396:402	MSTPTLE	FBXW7	0.6569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons