DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: DEG_SCF_FBW7_1

Location: 756:762

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 79.2

COIL: 0.9179

CONS_SCORE: 0.237

DSS_SCORE: 0.6355

HELIX: 0.0211

FCONS_SCORE: 0.8525

RIG_SCORE: 0.6207

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N770K	TCGA-CA-6717	COAD	TCGA	VTTPGHS	DEG_SCF_FBW7_1	0.1111
p.N770K	DO8264	COAD	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.1111
p.D749G	TCGA-D1-A103	UCEC	TCGA	VTTPGHS	DEG_SCF_FBW7_1	0.1389
p.D749G	DO42312	UCEC	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.1389
p.D755G	TCGA-DD-AAVY	LIHC	TCGA	VTTPGHS	DEG_SCF_FBW7_1	0.3056
p.D755G	DO52284	LIHC	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.3056
p.G760D	TCGA-DU-6392	LGG	TCGA	VTTPGHS	DEG_SCF_FBW7_1	0.6087
p.G760D	DO22237	LGG	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.6087
p.G750V	TCGA-EK-A2RM	CESC	TCGA	VTTPGHS	DEG_SCF_FBW7_1	0.1667
p.G750V	DO49956	CESC	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.1667
p.T763K	DO228986	LICA	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.75
p.S762Y	DO229045	LICA	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.8231
p.G750R	DO50846	LICA	ICGC	VTTPGHS	DEG_SCF_FBW7_1	0.1667
p.P759S	SIDM00572	Gastric Carcinoma	GDSC	VTTPGHS	DEG_SCF_FBW7_1	0.6752
p.P759S	ACH-000911	Gastric Cancer	CCLE	VTTPGHS	DEG_SCF_FBW7_1	0.6752
p.P759S	NUGC-3	stomach	COSMIC	VTTPGHS	DEG_SCF_FBW7_1	0.6752
p.T758I	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VTTPGHS	DEG_SCF_FBW7_1	0.8189
p.T758I	ACH-000869	Lung Cancer	CCLE	VTTPGHS	DEG_SCF_FBW7_1	0.8189
p.T758I	NCI-H1568	lung	COSMIC	VTTPGHS	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SCF_FBW7_1	756:762	VTTPGHS	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons