DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: DEG_SCF_FBW7_1

Location: 1041:1047

E3 ligase: FBXW7

DEGRON score: 0.9792

ASA_SCORE: 96.4857

COIL: 0.946

CONS_SCORE: 0.3247

DSS_SCORE: 0.6985

HELIX: 0.021

FCONS_SCORE: 0.9929

RIG_SCORE: 0.6289

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1045L	TCGA-85-A4CL	LUSC	TCGA	PATPRFS	DEG_SCF_FBW7_1	0.7316
p.R1045L	DO45454	LUSC	ICGC	PATPRFS	DEG_SCF_FBW7_1	0.7316
p.R1045H	DO233634	GACA	ICGC	PATPRFS	DEG_SCF_FBW7_1	0.7133
p.R1045P	DO221456	AML	ICGC	PATPRFS	DEG_SCF_FBW7_1	0.6401
p.A1042T	TCGA-AX-A3FS	UCEC	TCGA	PATPRFS	DEG_SCF_FBW7_1	0.6028
p.A1042T	TCGA-PG-A917	UCEC	TCGA	PATPRFS	DEG_SCF_FBW7_1	0.6028
p.A1042T	DO40879	UCEC	ICGC	PATPRFS	DEG_SCF_FBW7_1	0.6028
p.A1042T	DO52424	UCEC	ICGC	PATPRFS	DEG_SCF_FBW7_1	0.6028
p.P1057Q	TCGA-D3-A2J6	SKCM	TCGA	PATPRFS	DEG_SCF_FBW7_1	0.0556
p.P1057Q	DO37901	SKCM	ICGC	PATPRFS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SCF_FBW7_1	1041:1047	PATPRFS	FBXW7	0.9792	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons