DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: DEG_SCF_FBW7_1

Location: 1082:1089

E3 ligase: FBXW7

DEGRON score: 0.9887

ASA_SCORE: 82.3375

COIL: 0.9536

CONS_SCORE: 0.3208

DSS_SCORE: 0.7353

HELIX: 0.0213

FCONS_SCORE: 1.0602

RIG_SCORE: 0.5792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1083T	TCGA-A5-A0G2	UCEC	TCGA	PASTPSTT	DEG_SCF_FBW7_1	0.6028
p.A1083T	DO41235	UCEC	ICGC	PASTPSTT	DEG_SCF_FBW7_1	0.6028
p.D1078N	TCGA-BS-A0UV	UCEC	TCGA	PASTPSTT	DEG_SCF_FBW7_1	0.2222
p.D1078N	DO232761	PBCA	ICGC	PASTPSTT	DEG_SCF_FBW7_1	0.2222
p.D1078N	DO42793	UCEC	ICGC	PASTPSTT	DEG_SCF_FBW7_1	0.2222
p.D1078N	ACH-001132	Lymphoma	CCLE	PASTPSTT	DEG_SCF_FBW7_1	0.2222
p.P1086L	TCGA-FS-A1ZF	SKCM	TCGA	PASTPSTT	DEG_SCF_FBW7_1	0.7582
p.P1086L	DO38039	SKCM	ICGC	PASTPSTT	DEG_SCF_FBW7_1	0.7582
p.N1093S	TCGA-HU-A4H3	STAD	TCGA	PASTPSTT	DEG_SCF_FBW7_1	0.2222
p.N1093S	DO47903	STAD	ICGC	PASTPSTT	DEG_SCF_FBW7_1	0.2222
p.L1092F	DO229462	SKCA	ICGC	PASTPSTT	DEG_SCF_FBW7_1	0.25
p.V1072I	SIDM00284	Melanoma	GDSC	PASTPSTT	DEG_SCF_FBW7_1	0.0556
p.S1076N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PASTPSTT	DEG_SCF_FBW7_1	0.1667
p.S1076N	ACH-001127	Leukemia	CCLE	PASTPSTT	DEG_SCF_FBW7_1	0.1667
p.S1076N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPSTT	DEG_SCF_FBW7_1	0.1667
p.T1085P	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPSTT	DEG_SCF_FBW7_1	0.7031
p.T1085P	SCC90	upper_aerodigestive_tract	COSMIC	PASTPSTT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98088	Mucin-5AC	DEG_SCF_FBW7_1	4115:4122	PASTPSTT	FBXW7	0.9148	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SCF_FBW7_1	1082:1089	PASTPSTT	FBXW7	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons