DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PASTPSTT
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SCF_FBW7_1
Location:
4115:4122
E3 ligase:
FBXW7
DEGRON score:
0.9148
ASA_SCORE:
91.4875
COIL:
0.9504
CONS_SCORE:
0.2854
DSS_SCORE:
0.6526
HELIX:
0.0145
FCONS_SCORE:
0.9868
RIG_SCORE:
0.6031
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S4117C
SIDM00749
Non-Small Cell Lung Carcinoma
GDSC
PASTPSTT
DEG_SCF_FBW7_1
0.643
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PASTPSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P98088
Mucin-5AC
DEG_SCF_FBW7_1
4115:4122
PASTPSTT
FBXW7
0.9148
More...
Q71F56
Mediator of RNA polymerase II transcription subunit 13-like
DEG_SCF_FBW7_1
1082:1089
PASTPSTT
FBXW7
0.9887
More...