DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: LIG_APCC_ABBA_1

Location: 169:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6343

ASA_SCORE: 40.3333

COIL: 0.4088

CONS_SCORE: 0.5563

DSS_SCORE: 0.0575

HELIX: 0.0177

FCONS_SCORE: 1.2661

RIG_SCORE: 0.8186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S160I	TCGA-AA-3815	COAD	TCGA	FFLHGE	LIG_APCC_ABBA_1	0.0833
p.S160I	DO9924	COAD	ICGC	FFLHGE	LIG_APCC_ABBA_1	0.0833
p.H172N	TCGA-EO-A22X	UCEC	TCGA	FFLHGE	LIG_APCC_ABBA_1	0.7423
p.H172N	DO43907	UCEC	ICGC	FFLHGE	LIG_APCC_ABBA_1	0.7423
p.A184D	DO229032	LICA	ICGC	FFLHGE	LIG_APCC_ABBA_1	0.0556
p.A184V	SIDM01588	Endometrial Carcinoma	GDSC	FFLHGE	LIG_APCC_ABBA_1	0.0556
p.A184V	ACH-000993	Endometrial/Uterine Cancer	CCLE	FFLHGE	LIG_APCC_ABBA_1	0.0556
p.K159T	ACH-001645	Skin Cancer	CCLE	FFLHGE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	LIG_APCC_ABBA_1	169:174	FFLHGE	APC,CDC20,FZR1	0.6343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons