DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: DEG_SCF_FBW7_1

Location: 323:330

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 79.625

COIL: 0.9603

CONS_SCORE: 0.2852

DSS_SCORE: 0.6779

HELIX: 0.0099

FCONS_SCORE: 1.0814

RIG_SCORE: 0.6529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P318Q	TCGA-EB-A24C	SKCM	TCGA	MPLTPPTS	DEG_SCF_FBW7_1	0.1944
p.P318Q	DO37438	SKCM	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	0.1944
p.D317Y	TCGA-VQ-AA6I	STAD	TCGA	MPLTPPTS	DEG_SCF_FBW7_1	0.1667
p.D317Y	DO222398	STAD	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	0.1667
p.P331S	TCGA-W3-AA1V	SKCM	TCGA	MPLTPPTS	DEG_SCF_FBW7_1	0.3056
p.P331S	DO51276	SKCM	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	0.3056
p.P331S	SIDM00948	Burkitt's Lymphoma	GDSC	MPLTPPTS	DEG_SCF_FBW7_1	0.3056
p.P331S	ACH-002232	Lymphoma	CCLE	MPLTPPTS	DEG_SCF_FBW7_1	0.3056
p.P331S	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	MPLTPPTS	DEG_SCF_FBW7_1	0.3056
p.S339R	DO229465	SKCA	ICGC	MPLTPPTS	DEG_SCF_FBW7_1	0.0833
p.M323I	SIDM00285	Neuroblastoma	GDSC	MPLTPPTS	DEG_SCF_FBW7_1	0.6507
p.M323I	CHP-134	autonomic_ganglia	COSMIC	MPLTPPTS	DEG_SCF_FBW7_1	0.6507
p.S314N	SIDM01640	Acute Myeloid Leukemia	GDSC	MPLTPPTS	DEG_SCF_FBW7_1	0.0833
p.S314N	ACH-000602	Leukemia	CCLE	MPLTPPTS	DEG_SCF_FBW7_1	0.0833
p.C321R	ACH-000974	Endometrial/Uterine Cancer	CCLE	MPLTPPTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SCF_FBW7_1	323:330	MPLTPPTS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons