DegronMD

Uniprot ID: Q71F56

Source protein: Mediator of RNA polymerase II transcription subunit 13-like

Source gene: MED13L

Class: DEG_COP1_1

Location: 2049:2059

E3 ligase: COP1

DEGRON score: 0.9384

ASA_SCORE: 68.8

COIL: 0.9608

CONS_SCORE: 0.3014

DSS_SCORE: 0.6915

HELIX: 0.019

FCONS_SCORE: 1.0235

RIG_SCORE: 0.5166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2063F	TCGA-CV-7568	HNSC	TCGA	SSPNSSPVPSP	DEG_COP1_1	0.2222
p.S2063F	DO14160	HNSC	ICGC	SSPNSSPVPSP	DEG_COP1_1	0.2222
p.P2055Q	DO229035	LICA	ICGC	SSPNSSPVPSP	DEG_COP1_1	0.5924
p.T2044S	DO229052	LICA	ICGC	SSPNSSPVPSP	DEG_COP1_1	0.1944
p.G2040S	DO231102	LUSC	ICGC	SSPNSSPVPSP	DEG_COP1_1	0.0833
p.P2062L	DO219878	SKCA	ICGC	SSPNSSPVPSP	DEG_COP1_1	0.25
p.S2049P	ACH-000999	Colon/Colorectal Cancer	CCLE	SSPNSSPVPSP	DEG_COP1_1	0.6752
p.S2049P	SNU-1040	large_intestine	COSMIC	SSPNSSPVPSP	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_COP1_1	2049:2059	SSPNSSPVPSP	COP1	0.9384	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons