DegronMD - Q8IVL0(NAV3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S261R	TCGA-17-Z028	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.8538
p.A1521S	TCGA-17-Z050	LUAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.1389
p.Q300P	TCGA-22-0940	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5924
p.Q300P	DO26794	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.5924
p.G298V	TCGA-22-5485	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.G298V	DO26553	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.P251T	TCGA-2H-A9GK	ESCA	TCGA	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.S313R	TCGA-43-A474	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.S313R	DO45490	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.P1460T	TCGA-55-6985	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1667
p.P1460T	DO25659	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1667
p.N1500H	TCGA-55-7994	LUAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.0833
p.N1500H	DO45311	LUAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.0833
p.A1283E	TCGA-56-8628	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0556
p.A1283E	DO45433	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0556
p.G1456R	TCGA-60-2714	LUSC	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.G1456R	DO26530	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.G1456V	TCGA-60-2714	LUSC	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.G1456V	DO234401	ESAD	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.G1456V	DO26530	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.T1266N	TCGA-66-2763	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.25
p.T1266N	DO27620	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.25
p.S1273L	TCGA-75-6214	LUAD	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7667
p.S1273L	TCGA-UY-A78P	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7667
p.S1273L	DO219036	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7667
p.S1273L	DO24830	LUAD	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7667
p.A1466D	TCGA-86-A4JF	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.7793
p.A1466D	DO45317	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.7793
p.A1472D	TCGA-95-7039	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2778
p.A1472D	DO23907	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2778
p.D1510N	TCGA-A5-A0G1	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	TCGA-AP-A1DV	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	TCGA-D1-A16X	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	TCGA-EO-A22X	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	DO222880	MELA	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	DO43186	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	DO41799	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	DO43907	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	DO42472	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	ACH-000795	Leukemia	CCLE	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.D1510N	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5821
p.V1269M	TCGA-A5-A0R8	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7208
p.V1269M	DO42584	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7208
p.D280N	TCGA-AK-3436	KIRC	TCGA	PPNY	ITCH	284:287	Mutation rewiring degron network	0.2222
p.D280N	DO20239	KIRC	ICGC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.2222
p.K1270E	TCGA-AP-A056	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.591
p.K1270E	DO43971	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.591
p.V1544I	TCGA-B0-5088	KIRC	TCGA	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1111
p.V1544I	DO17742	KIRC	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1111
p.D1510Y	TCGA-B5-A0JY	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.6214
p.D1510Y	DO43041	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.6214
p.K1474I	TCGA-CA-6717	COAD	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation substituting flanking lysine	0.3333
p.K1474I	DO8264	COAD	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation substituting flanking lysine	0.3333
p.N1500D	TCGA-CA-6717	COAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.0833
p.N1500D	DO8264	COAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.0833
p.D1506Y	TCGA-CA-6717	COAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.25
p.D1506Y	DO8264	COAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.25
p.V263I	TCGA-D3-A51E	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.V263I	DO47465	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.S1463F	TCGA-D3-A8GM	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation blocking phosphorylation signal	0.6944
p.S1463F	DO50288	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation blocking phosphorylation signal	0.6944
p.E292K	TCGA-D3-A8GQ	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.E292K	TCGA-D3-A8GQ	SKCM	TCGA	PPNY	ITCH	284:287	Mutation rewiring degron network	0.1944
p.E292K	TCGA-QQ-A8VG	SARC	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.E292K	TCGA-QQ-A8VG	SARC	TCGA	PPNY	ITCH	284:287	Mutation rewiring degron network	0.1944
p.E292K	DO220260	SARC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.E292K	DO220260	SARC	ICGC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.1944
p.E292K	DO51246	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.E292K	DO51246	SKCM	ICGC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.1944
p.S301L	TCGA-DA-A1HY	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7667
p.S301L	DO222699	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7667
p.S301L	DO229494	SKCA	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7667
p.S301L	DO37409	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7667
p.L1282S	TCGA-DD-AADC	LIHC	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0833
p.L1282S	DO52230	LIHC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0833
p.G1473R	TCGA-DD-AADG	LIHC	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.25
p.G1473R	DO219571	LIHC	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.25
p.P1278H	TCGA-EE-A2M8	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.P1278H	DO38075	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.S1556T	TCGA-F5-6814	READ	TCGA	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation altering degron motif	0.6005
p.S1556T	DO36556	READ	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation altering degron motif	0.6005
p.G258R	TCGA-F7-A50I	HNSC	TCGA	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.6457
p.G258R	DO44449	HNSC	ICGC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.6457
p.S1468P	TCGA-FI-A2D5	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.7863
p.S1468P	DO41331	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.7863
p.D1510H	TCGA-FP-A8CX	STAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.6577
p.D1510H	DO50126	STAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.6577
p.L1558I	TCGA-FS-A1ZG	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2778
p.L1558I	DO37523	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2778
p.S1262C	TCGA-G2-A3IE	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.S1262C	DO767	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.S1262C	DO48222	ESCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.S295Y	TCGA-H7-A6C5	HNSC	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.S295Y	TCGA-H7-A6C5	HNSC	TCGA	PPNY	ITCH	284:287	Mutation rewiring degron network	0.1111
p.S295Y	DO49996	HNSC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.S295Y	DO49996	HNSC	ICGC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.1111
p.S1260C	TCGA-HG-A2PA	CESC	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0833
p.S1260C	DO6311	CESC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0833
p.P312H	TCGA-L9-A7SV	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.P312H	DO49875	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.P1464L	TCGA-R6-A8WG	ESCA	TCGA	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2778
p.S1262F	TCGA-UY-A78O	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.S1262F	DO219035	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.E1563K	TCGA-ZF-A9R7	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1389
p.E1563K	DO219064	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1389
p.G265E	DO228102	EOPC	ICGC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2222
p.S1465Y	DO233674	GACA	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation blocking phosphorylation signal	0.75
p.L1282F	DO232019	LICA	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.0833
p.V1552L	DO229045	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation altering degron motif	0.6765
p.G304D	DO224563	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.S1279N	DO231086	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1667
p.P311T	DO231106	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.V254L	DO26469	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.25
p.P1503L	DO222743	MELA	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.1667
p.S1548L	DO51467	PACA	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2222
p.S1478Y	DO52124	PAEN	ICGC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1111
p.T1555N	DO232761	PBCA	ICGC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation altering degron motif	0.7055
p.S1499T	DO46897	RECA	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.0556
p.S1508F	DO229453	SKCA	ICGC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.3056
p.G290E	DO229272	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G290E	DO229272	THCA	ICGC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.25
p.G290E	DO229213	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G290E	DO229213	THCA	ICGC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.25
p.L269F	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1111
p.S1272Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.712
p.S1272Y	ACH-000789	Lung Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.712
p.S1272Y	NCI-H810	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.712
p.R247K	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.R247K	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.L1511V	SIDM00848	Ewing's Sarcoma	GDSC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5654
p.L1511V	ACH-000052	Bone Cancer	CCLE	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5654
p.L1511V	A673	bone	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.5654
p.P299L	SIDM00660	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7582
p.P299L	ACH-000985	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7582
p.P299L	LS-411N	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7582
p.V1544A	SIDM00487	Colorectal Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1111
p.V1544A	CCK-81	large intestine	COSMIC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1111
p.Q1505K	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.2222
p.Q1505K	ACH-000945	Lung Cancer	CCLE	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.2222
p.Q1505K	NCI-H650	lung	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.2222
p.H1545N	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1389
p.H1545N	ACH-000744	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1389
p.H1545N	NCI-H1623	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.1389
p.V1274A	SIDM00537	Colorectal Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.3056
p.V1274A	ACH-001345	Colon/Colorectal Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.3056
p.V1274A	GP5d	large intestine	COSMIC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.3056
p.A1504T	SIDM01721	Non-Cancerous	GDSC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.1944
p.A1504T	ACH-002344	Non-Cancerous	CCLE	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.1944
p.S1507A	SIDM00312	Plasma Cell Myeloma	GDSC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.2778
p.S1507A	ACH-000183	Myeloma	CCLE	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.2778
p.S1507A	L-363	haematopoietic and lymphoid tissue	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.2778
p.L1517F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.25
p.L1517F	ACH-001127	Leukemia	CCLE	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.25
p.L1517F	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.25
p.S1548A	SIDM00850	Gastric Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2222
p.S1548A	ACH-000880	Gastric Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2222
p.S1548A	AGS	stomach	COSMIC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2222
p.G1473E	SIDM00118	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.25
p.G1473E	ACH-001081	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.25
p.G1473E	HCC2998	large intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.25
p.V263F	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.V263F	ACH-000912	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.P1264H	ACH-000568	Breast Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.T1280I	ACH-000776	Brain Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.S1459P	ACH-000937	Leukemia	CCLE	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation blocking phosphorylation signal	0.5833
p.T1272M	TYK-nu	ovary	COSMIC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7423
p.M296I	HCT-15	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.25
p.M296I	HCT-15	large intestine	COSMIC	PPNY	ITCH	284:287	Mutation rewiring degron network	0.0833
p.H1550N	FADU	upper aerodigestive tract	COSMIC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation rewiring degron network	0.2778
p.S1512A	HCT-15	large intestine	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation altering degron motif	0.7588
p.T1520A	HT-115	large intestine	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.1667
p.S1280N	BV-173	haematopoietic and lymphoid tissue	COSMIC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1389
p.D1273Y	NCI-H128	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7325
p.E1456V	NCI-H1092	lung	COSMIC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.L1502F	CAL-12T	lung	COSMIC	FDLYDD	LIG_APCC_ABBA_1	1509:1514	Mutation rewiring degron network	0.1389
p.I1470M	PCI-30	upper aerodigestive tract	COSMIC	AMSSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.7618
p.D275H	CHP-134	autonomic ganglia	COSMIC	PPNY	ITCH	284:287	Mutation blocking phosphorylation signal	0.5278
p.R265C	MCC13	skin	COSMIC	AGSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2222
p.L1269I	CW-2	large intestine	COSMIC	VKSSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7174
p.S1552P	CCK-81	large intestine	COSMIC	VSSTS	DEG_SPOP_SBC_1	1552:1556	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAV3

UniProt ID: Q8IVL0

Entrez ID: 89795

Protein name: Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAV3 in