DegronMD

Uniprot ID: Q8IVL0

Source protein: Neuron navigator 3

Source gene: NAV3

Class: LIG_APCC_ABBA_1

Location: 1509:1514

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6993

ASA_SCORE: 63.9333

COIL: 0.743

CONS_SCORE: 0.3085

DSS_SCORE: 0.4736

HELIX: 0.1778

FCONS_SCORE: 0.9182

RIG_SCORE: 0.7709

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1521S	TCGA-17-Z050	LUAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.1389
p.N1500H	TCGA-55-7994	LUAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.0833
p.N1500H	DO45311	LUAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.0833
p.D1510N	TCGA-A5-A0G1	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	TCGA-AP-A1DV	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	TCGA-D1-A16X	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	TCGA-EO-A22X	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	DO222880	MELA	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	DO43186	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	DO41799	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	DO43907	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	DO42472	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	ACH-000795	Leukemia	CCLE	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510N	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.5821
p.D1510Y	TCGA-B5-A0JY	UCEC	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.6214
p.D1510Y	DO43041	UCEC	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.6214
p.N1500D	TCGA-CA-6717	COAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.0833
p.N1500D	DO8264	COAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.0833
p.D1506Y	TCGA-CA-6717	COAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.25
p.D1506Y	DO8264	COAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.25
p.D1510H	TCGA-FP-A8CX	STAD	TCGA	FDLYDD	LIG_APCC_ABBA_1	0.6577
p.D1510H	DO50126	STAD	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.6577
p.P1503L	DO222743	MELA	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.1667
p.S1499T	DO46897	RECA	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.0556
p.S1508F	DO229453	SKCA	ICGC	FDLYDD	LIG_APCC_ABBA_1	0.3056
p.L1511V	SIDM00848	Ewing's Sarcoma	GDSC	FDLYDD	LIG_APCC_ABBA_1	0.5654
p.L1511V	ACH-000052	Bone Cancer	CCLE	FDLYDD	LIG_APCC_ABBA_1	0.5654
p.L1511V	A673	bone	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.5654
p.Q1505K	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FDLYDD	LIG_APCC_ABBA_1	0.2222
p.Q1505K	ACH-000945	Lung Cancer	CCLE	FDLYDD	LIG_APCC_ABBA_1	0.2222
p.Q1505K	NCI-H650	lung	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.2222
p.A1504T	SIDM01721	Non-Cancerous	GDSC	FDLYDD	LIG_APCC_ABBA_1	0.1944
p.A1504T	ACH-002344	Non-Cancerous	CCLE	FDLYDD	LIG_APCC_ABBA_1	0.1944
p.S1507A	SIDM00312	Plasma Cell Myeloma	GDSC	FDLYDD	LIG_APCC_ABBA_1	0.2778
p.S1507A	ACH-000183	Myeloma	CCLE	FDLYDD	LIG_APCC_ABBA_1	0.2778
p.S1507A	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.2778
p.L1517F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	FDLYDD	LIG_APCC_ABBA_1	0.25
p.L1517F	ACH-001127	Leukemia	CCLE	FDLYDD	LIG_APCC_ABBA_1	0.25
p.L1517F	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.25
p.S1512A	HCT-15	large_intestine	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.7588
p.T1520A	HT-115	large_intestine	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.1667
p.L1502F	CAL-12T	lung	COSMIC	FDLYDD	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FDLYDD

Degron related mutations and impact score

Drug responses associated with NAV3 mutations

All proteins holding degron of FDLYDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVL0	Neuron navigator 3	LIG_APCC_ABBA_1	1509:1514	FDLYDD	APC,CDC20,FZR1	0.6993	More...