DegronMD

Uniprot ID: Q8IVL0

Source protein: Neuron navigator 3

Source gene: NAV3

Class: DEG_SPOP_SBC_1

Location: 1466:1470

E3 ligase: SPOP

DEGRON score: 0.9941

ASA_SCORE: 67.74

COIL: 0.7786

CONS_SCORE: 0.352

DSS_SCORE: 0.4513

HELIX: 0.1252

FCONS_SCORE: 0.9705

RIG_SCORE: 0.6151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1460T	TCGA-55-6985	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1667
p.P1460T	DO25659	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.G1456R	TCGA-60-2714	LUSC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.0556
p.G1456R	DO26530	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.G1456V	TCGA-60-2714	LUSC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.0556
p.G1456V	DO234401	ESAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.G1456V	DO26530	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.A1466D	TCGA-86-A4JF	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7793
p.A1466D	DO45317	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7793
p.A1472D	TCGA-95-7039	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2778
p.A1472D	DO23907	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2778
p.K1474I	TCGA-CA-6717	COAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.3333
p.K1474I	DO8264	COAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.3333
p.S1463F	TCGA-D3-A8GM	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.6944
p.S1463F	DO50288	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.6944
p.G1473R	TCGA-DD-AADG	LIHC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.25
p.G1473R	DO219571	LIHC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.25
p.S1468P	TCGA-FI-A2D5	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7863
p.S1468P	DO41331	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7863
p.P1464L	TCGA-R6-A8WG	ESCA	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2778
p.S1465Y	DO233674	GACA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.75
p.S1478Y	DO52124	PAEN	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.G1473E	SIDM00118	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.25
p.G1473E	ACH-001081	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.25
p.G1473E	HCC2998	large_intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.25
p.S1459P	ACH-000937	Leukemia	CCLE	AMSSS	DEG_SPOP_SBC_1	0.5833
p.E1456V	NCI-H1092	lung	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.I1470M	PCI-30	upper_aerodigestive_tract	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AMSSS

Degron related mutations and impact score

Drug responses associated with NAV3 mutations

All proteins holding degron of AMSSS