FUNCTION: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to...
FUNCTION: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}.
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GO - Biological processes (BP):
regulation of cytoskeleton organization [GO:0051493]; regulation of signal transduction [GO:0009966]...
regulation of cytoskeleton organization [GO:0051493]; regulation of signal transduction [GO:0009966]
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GO - Molecular function (MF):
actin binding [GO:0003779]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]...
actin binding [GO:0003779]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]
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GO - Cellular component (CC):
actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]...
actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]
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