DegronMD

Uniprot ID: Q8N556

Source protein: Actin filament-associated protein 1

Source gene: AFAP1

Class: DEG_SPOP_SBC_1

Location: 117:121

E3 ligase: SPOP

DEGRON score: 0.9445

ASA_SCORE: 65.02

COIL: 0.7146

CONS_SCORE: 0.5649

DSS_SCORE: 0.558

HELIX: 0.2248

FCONS_SCORE: 0.9976

RIG_SCORE: 0.6383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E128D	TCGA-19-5956	GBM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1389
p.E128D	DO13863	GBM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1389
p.S111L	TCGA-CV-7090	HNSC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1667
p.S111L	DO14238	HNSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.D131E	DO912	BOCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.D131G	DO227976	COCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.T110K	DO229031	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons