DegronMD

Uniprot ID: Q8TED9

Source protein: Actin filament-associated protein 1-like 1

Source gene: AFAP1L1

Class: DEG_SPOP_SBC_1

Location: 184:188

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 69.74

COIL: 0.7286

CONS_SCORE: 0.6944

DSS_SCORE: 0.606

HELIX: 0.2172

FCONS_SCORE: 1.2074

RIG_SCORE: 0.5975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S177G	TCGA-A6-3809	COAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1389
p.S177G	DO8722	COAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1389
p.A184T	TCGA-AX-A2HD	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7139
p.A184T	DO42608	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7139
p.S191T	TCGA-BR-6452	STAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.25
p.S191T	DO38404	STAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.25
p.K176N	TCGA-D7-A74A	STAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2222
p.K176N	DO50123	STAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2222
p.E196Q	TCGA-DK-A3X1	BLCA	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1111
p.E196Q	DO447	BLCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.E197D	SIDM00781	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.E197D	SIDM00780	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.E197D	ACH-000967	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.0833
p.E197D	ACH-001199	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.0833
p.E197D	SNU-C2B	large_intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons