DegronMD

Uniprot ID: Q68CP9

Source protein: AT-rich interactive domain-containing protein 2

Source gene: ARID2

Class: DEG_SPOP_SBC_1

Location: 987:991

E3 ligase: SPOP

DEGRON score: 0.8843

ASA_SCORE: 92.36

COIL: 0.9542

CONS_SCORE: 0.2705

DSS_SCORE: 0.7945

HELIX: 0.029

FCONS_SCORE: 1.0319

RIG_SCORE: 0.5459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q997H	TCGA-44-8120	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1667
p.S990L	TCGA-AP-A056	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7667
p.S990L	TCGA-ER-A19E	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7667
p.P978Q	TCGA-D3-A2JP	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.0833
p.S992Y	TCGA-D3-A8GL	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.3056
p.T993S	TCGA-GL-A59R	KIRP	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2778
p.H994Y	DO37583	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.25
p.G979C	DO223286	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.S989L	ACH-001991	Primary	CCLE	AMSSS	DEG_SPOP_SBC_1	0.7667
p.S988A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.7588
p.S988A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.7588
p.P982Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.1944
p.P982Q	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.1944
p.I986S	EN	endometrium	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons