DegronMD - P25054(APC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L2144M	TCGA-05-4396	LUAD	TCGA	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1667
p.L2144M	DO23838	LUAD	ICGC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1667
p.R2759H	TCGA-06-5416	GBM	TCGA	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation altering degron motif	0.7133
p.R2759H	DO10880	GBM	ICGC	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation altering degron motif	0.7133
p.H806R	TCGA-12-0827	GBM	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1111
p.H806R	DO12538	GBM	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1111
p.P2808A	TCGA-29-1776	OV	TCGA	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation rewiring degron network	0.0833
p.P2808A	DO30810	OV	ICGC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation rewiring degron network	0.0833
p.S2794I	TCGA-29-1781	OV	TCGA	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation blocking phosphorylation signal	0.75
p.S2794I	DO29578	OV	ICGC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation blocking phosphorylation signal	0.75
p.D328Y	TCGA-2Z-A9JR	KIRP	TCGA	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.D328Y	DO219685	KIRP	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.S2794T	TCGA-43-2581	LUSC	TCGA	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation blocking phosphorylation signal	0.75
p.S2794T	DO26602	LUSC	ICGC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation blocking phosphorylation signal	0.75
p.R1882S	TCGA-61-1919	OV	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2778
p.R1882S	DO32410	OV	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2778
p.E868Q	TCGA-66-2727	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.E868Q	DO26478	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.Q2154E	TCGA-85-8666	LUSC	TCGA	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation altering degron motif	0.5633
p.Q2154E	DO45547	LUSC	ICGC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation altering degron motif	0.5633
p.R876Q	TCGA-A5-A0G2	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.R876Q	DO41235	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.S331P	TCGA-A5-A1OF	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation blocking phosphorylation signal	0.6389
p.S331P	DO42568	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation blocking phosphorylation signal	0.6389
p.S2755Y	TCGA-A5-A1OF	UCEC	TCGA	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.2778
p.S2755Y	TCGA-A5-A1OF	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1667
p.S2755Y	TCGA-KQ-A41N	BLCA	TCGA	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.2778
p.S2755Y	TCGA-KQ-A41N	BLCA	TCGA	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1667
p.S2755Y	DO223588	BLCA	ICGC	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.2778
p.S2755Y	DO223588	BLCA	ICGC	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1667
p.S2755Y	DO42568	UCEC	ICGC	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.2778
p.S2755Y	DO42568	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1667
p.R2801W	TCGA-AA-A00N	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation rewiring degron network	0.2778
p.R2801W	DO9876	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation rewiring degron network	0.2778
p.S2601R	TCGA-AB-2827	LAML	TCGA	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation altering degron motif	0.6316
p.S2601R	DO22032	LAML	ICGC	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation altering degron motif	0.6316
p.P2761L	TCGA-AG-A002	READ	TCGA	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation altering degron motif	0.7582
p.P2761L	TCGA-AG-A002	READ	TCGA	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation altering degron motif	0.7582
p.R2613I	TCGA-AJ-A3EL	UCEC	TCGA	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.1111
p.R2613I	TCGA-AJ-A3EL	UCEC	TCGA	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.2778
p.R2613I	DO41542	UCEC	ICGC	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.1111
p.R2613I	DO41542	UCEC	ICGC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.2778
p.R786C	TCGA-AP-A051	UCEC	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1667
p.R786C	DO42673	UCEC	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1667
p.T828N	TCGA-AP-A1E0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.2222
p.T828N	DO43154	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.2222
p.S1971Y	TCGA-AX-A05Z	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.0556
p.S1971Y	TCGA-D1-A103	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.0556
p.S1971Y	DO40884	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.0556
p.S1971Y	DO42312	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.0556
p.R786H	TCGA-AX-A1CE	UCEC	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1667
p.R786H	DO233665	GACA	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1667
p.R786H	DO42280	UCEC	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1667
p.N2624D	TCGA-B5-A0JY	UCEC	TCGA	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1944
p.N2624D	DO43041	UCEC	ICGC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1944
p.A289V	TCGA-B5-A11E	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.2778
p.A289V	DO41644	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.2778
p.A1892V	TCGA-B5-A11E	UCEC	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2222
p.A1892V	DO41644	UCEC	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2222
p.E1880K	TCGA-B5-A11R	UCEC	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2222
p.E1880K	DO43787	UCEC	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2222
p.S833I	TCGA-B5-A1MX	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation altering degron motif	0.623
p.S833I	DO41999	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation altering degron motif	0.623
p.E1886K	TCGA-B5-A3FA	UCEC	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation altering degron motif	0.7022
p.E1886K	DO52402	UCEC	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation altering degron motif	0.7022
p.G2775V	TCGA-B5-A3FC	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.0556
p.G2775V	DO41871	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.0556
p.G2145R	TCGA-BH-A0HF	BRCA	TCGA	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1944
p.G2145R	DO1749	BRCA	ICGC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1944
p.R302Q	TCGA-CA-6717	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1389
p.R302Q	DO8264	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1389
p.R805Q	TCGA-CA-6717	COAD	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1389
p.R805Q	DO8264	COAD	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.1389
p.G2360S	TCGA-CK-5914	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.0556
p.G2360S	DO9658	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.0556
p.R283Q	TCGA-CV-6935	HNSC	TCGA	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1111
p.R283Q	TCGA-CV-A6K1	HNSC	TCGA	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1111
p.R283Q	DO15238	HNSC	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1111
p.R283Q	DO52078	HNSC	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1111
p.D842V	TCGA-CV-7435	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.1667
p.D842V	DO14918	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.1667
p.A1884S	TCGA-CZ-5468	KIRC	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation altering degron motif	0.6477
p.A1884S	DO18332	KIRC	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation altering degron motif	0.6477
p.K1888N	TCGA-D3-A3CE	SKCM	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation altering degron motif	0.5806
p.K1888N	DO37405	SKCM	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation altering degron motif	0.5806
p.A1879S	TCGA-D5-6926	COAD	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.1944
p.A1879S	DO8530	COAD	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.1944
p.P2346S	TCGA-EE-A29E	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation altering degron motif	0.6752
p.P2346S	DO37831	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation altering degron motif	0.6752
p.H864N	TCGA-EE-A2MM	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1667
p.H864N	DO37770	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1667
p.R332Q	TCGA-EI-6917	READ	TCGA	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.R332Q	DO36881	READ	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.S294F	TCGA-F5-6814	READ	TCGA	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.7982
p.S294F	DO36556	READ	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.7982
p.S846Y	TCGA-KQ-A41N	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.0556
p.S846Y	DO223588	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.0556
p.E868D	TCGA-VQ-A8DV	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.E868D	DO51753	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.S299C	TCGA-VS-AA62	CESC	TCGA	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.2222
p.S299C	DO219745	CESC	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.2222
p.Q2804P	TCGA-WC-AA9A	UVM	TCGA	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation rewiring degron network	0.1944
p.E1891Q	TCGA-XF-A9T8	BLCA	TCGA	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.25
p.E1891Q	DO51927	BLCA	ICGC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.25
p.P865S	TCGA-ZF-A9R9	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1944
p.P865S	DO219066	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1944
p.E1985K	TCGA-ZF-AA4W	BLCA	TCGA	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation altering degron motif	0.591
p.E1985K	DO219089	BLCA	ICGC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation altering degron motif	0.591
p.Q341L	DO225037	BRCA	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.3056
p.Q341L	DO227629	BRCA	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.3056
p.S843R	DO222404	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.1389
p.P2338H	DO8898	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.1111
p.S294Y	DO222762	COCA	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.712
p.S2350F	DO234253	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation altering degron motif	0.7982
p.R302P	DO234269	ESAD	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1389
p.S2621C	DO234285	ESAD	ICGC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation blocking phosphorylation signal	0.7222
p.R845H	DO233764	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.0833
p.D326Y	DO233904	GACA	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.G877D	DO11854	GBM	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.25
p.R2791W	DO228194	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation rewiring degron network	0.2222
p.R302L	DO228952	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1389
p.S293I	DO228976	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.7341
p.D329Y	DO228985	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1389
p.S2793I	DO229045	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation blocking phosphorylation signal	0.7222
p.S2755T	DO23210	LINC	ICGC	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.2778
p.S2755T	DO23210	LINC	ICGC	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1667
p.R838S	DO52676	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.2778
p.S881F	DO222595	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1389
p.M347V	DO35242	PACA	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1389
p.D328V	DO51495	PACA	ICGC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.S2625C	DO227891	PBCA	ICGC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1667
p.Q2154P	DO232761	PBCA	ICGC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation altering degron motif	0.5924
p.K2357T	DO47092	RECA	ICGC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation substituting flanking lysine	0.25
p.P1993A	SIDM02048	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1111
p.S2358P	SIDM01964	Esophageal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.1111
p.G2145V	SIDM00455	Pancreatic Carcinoma	GDSC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1944
p.G2145V	ACH-000599	Pancreatic Cancer	CCLE	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1944
p.G2145V	PA-TU-8902	pancreas	COSMIC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation rewiring degron network	0.1944
p.N862K	SIDM00594	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1111
p.N862K	CMK	haematopoietic and lymphoid tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1111
p.N862K	HEL	haematopoietic and lymphoid tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1111
p.S2596A	SIDM00057	Neuroblastoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.1944
p.S2596A	ACH-000676	Brain Cancer	CCLE	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.1944
p.S2596A	ACH-002389	Neuroblastoma	CCLE	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.1944
p.S2596A	ACN	autonomic ganglia	COSMIC	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.1944
p.P870S	SIDM00650	Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation altering degron motif	0.6752
p.P870S	SIDM00907	Burkitt's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation altering degron motif	0.6752
p.P870S	SIDM01681	Non-Cancerous	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation altering degron motif	0.6752
p.P870S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation altering degron motif	0.6752
p.P870S	SIDM00785	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation altering degron motif	0.6752
p.I2756V	SIDM00282	Colorectal Carcinoma	GDSC	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.3056
p.I2756V	SIDM00282	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1944
p.I2756V	ACH-000868	Lung Cancer	CCLE	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.3056
p.I2756V	ACH-000868	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1944
p.I2756V	ACH-000998	Colon/Colorectal Cancer	CCLE	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation rewiring degron network	0.3056
p.I2756V	ACH-000998	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation rewiring degron network	0.1944
p.S1973C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1111
p.S1973C	ACH-000309	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1111
p.S1973C	SK-LU-1	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1111
p.E2617K	SIDM01045	Endometrial Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation altering degron motif	0.7022
p.S1890L	SIDM00290	Gastric Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2778
p.S1890L	ACH-000847	Gastric Cancer	CCLE	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2778
p.S1890L	HGC-27	stomach	COSMIC	AKENK	DEG_APCC_KENBOX_2	1884:1888	Mutation rewiring degron network	0.2778
p.D807G	SIDM00564	Ovarian Carcinoma	GDSC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.0833
p.D807G	ACH-000527	Ovarian Cancer	CCLE	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.0833
p.D807G	OVISE	ovary	COSMIC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.0833
p.L2342F	SIDM00564	Ovarian Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.2222
p.L2342F	ACH-000527	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.2222
p.L2342F	OVISE	ovary	COSMIC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.2222
p.L2150V	SIDM00927	Small Cell Lung Carcinoma	GDSC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation altering degron motif	0.5654
p.L2150V	ACH-000871	Lung Cancer	CCLE	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation altering degron motif	0.5654
p.L2150V	NCI-H510A	lung	COSMIC	LTPDQE	DEG_SCF_FBW7_2	2150:2155	Mutation altering degron motif	0.5654
p.S2625I	SIDM00665	Gastric Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1667
p.S2625I	ACH-000616	Gastric Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1667
p.S2625I	Hs746T	stomach	COSMIC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1667
p.D2796G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation altering degron motif	0.6087
p.D2796G	ACH-000878	Lung Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation altering degron motif	0.6087
p.D2796G	HCC-15	lung	COSMIC	ADSTS	DEG_SPOP_SBC_1	2795:2799	Mutation altering degron motif	0.6087
p.E2617V	SIDM00954	Breast Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation altering degron motif	0.7693
p.E2617V	ACH-001820	Breast Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation altering degron motif	0.7693
p.E2617V	COLO-824	breast	COSMIC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation altering degron motif	0.7693
p.S331L	SIDM00534	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation blocking phosphorylation signal	0.6389
p.S331L	ACH-000986	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation blocking phosphorylation signal	0.6389
p.S331L	HT-115	large intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	336:340	Mutation blocking phosphorylation signal	0.6389
p.E1991D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1667
p.E1991D	ACH-000888	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1667
p.E1991D	NCI-H1793	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	1981:1985	Mutation rewiring degron network	0.1667
p.S2768R	SIDM01504	Small Cell Lung Carcinoma	GDSC	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation blocking phosphorylation signal	0.6667
p.S2768R	SIDM01504	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation blocking phosphorylation signal	0.6944
p.S2768R	ACH-000594	Lung Cancer	CCLE	VERTPFSS	DEG_SCF_FBW7_1	2757:2764	Mutation blocking phosphorylation signal	0.6667
p.S2768R	ACH-000594	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	2761:2765	Mutation blocking phosphorylation signal	0.6944
p.L2345I	SIDM00008	Ovarian Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.3056
p.L2345I	ACH-000796	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	2346:2350	Mutation rewiring degron network	0.3056
p.P865L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1944
p.P865L	ACH-000851	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.1944
p.F2620C	SIDM01611	Endometrial Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.3056
p.F2620C	ACH-000996	Endometrial/Uterine Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.3056
p.A2608T	SIDM01588	Endometrial Carcinoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.25
p.A2608T	SIDM01588	Endometrial Carcinoma	GDSC	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1389
p.A2608T	ACH-000993	Endometrial/Uterine Cancer	CCLE	SKENQ	DEG_APCC_KENBOX_2	2601:2605	Mutation rewiring degron network	0.25
p.A2608T	ACH-000993	Endometrial/Uterine Cancer	CCLE	IKENE	DEG_APCC_KENBOX_2	2615:2619	Mutation rewiring degron network	0.1389
p.D807Y	ACH-000975	Lung Cancer	CCLE	KQSLYGD	LIG_APCC_ABBAyCdc20_2	792:798	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APC

UniProt ID: P25054

Entrez ID: 324

Protein name: Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APC in