DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_SPOP_SBC_1

Location: 870:874

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 65.56

COIL: 0.8576

CONS_SCORE: 0.4746

DSS_SCORE: 0.6503

HELIX: 0.1124

FCONS_SCORE: 1.4358

RIG_SCORE: 0.6218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E868Q	TCGA-66-2727	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.E868Q	DO26478	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R876Q	TCGA-A5-A0G2	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.R876Q	DO41235	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.H864N	TCGA-EE-A2MM	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1667
p.H864N	DO37770	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1667
p.E868D	TCGA-VQ-A8DV	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	0.2778
p.E868D	DO51753	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	0.2778
p.P865S	TCGA-ZF-A9R9	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	0.1944
p.P865S	DO219066	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1944
p.G877D	DO11854	GBM	ICGC	PGTSS	DEG_SPOP_SBC_1	0.25
p.S881F	DO222595	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	0.1389
p.N862K	SIDM00594	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.N862K	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.N862K	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	0.1111
p.P870S	SIDM00650	Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6752
p.P870S	SIDM00907	Burkitt's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6752
p.P870S	SIDM01681	Non-Cancerous	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6752
p.P870S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6752
p.P870S	SIDM00785	Acute Myeloid Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	0.6752
p.P865L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	0.1944
p.P865L	ACH-000851	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	683:687	PGTSS	SPOP	0.9947	More...
P09871	Complement C1s subcomponent	DEG_SPOP_SBC_1	551:555	PGTSS	SPOP	0.8928	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	870:874	PGTSS	SPOP	0.9993	More...
P29400	Collagen alpha-5	DEG_SPOP_SBC_1	1453:1457	PGTSS	SPOP	0.8142	More...
P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	DEG_SPOP_SBC_1	1948:1952	PGTSS	SPOP	0.5066	More...
Q53H80	Akirin-2	DEG_SPOP_SBC_1	126:130	PGTSS	SPOP	0.9884	More...
Q5TDH0	Protein DDI1 homolog 2	DEG_SPOP_SBC_1	102:106	PGTSS	SPOP	0.9694	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	662:666	PGTSS	SPOP	0.9973	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1281:1285	PGTSS	SPOP	0.8916	More...
Q7L014	Probable ATP-dependent RNA helicase DDX46	DEG_SPOP_SBC_1	833:837	PGTSS	SPOP	0.9931	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	139:143	PGTSS	SPOP	0.9971	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	467:471	PGTSS	SPOP	0.9991	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	7:11	PGTSS	SPOP	0.7536	More...
Q8TDZ2	[F-actin]-monooxygenase MICAL1	DEG_SPOP_SBC_1	626:630	PGTSS	SPOP	0.9994	More...
Q8WTU0	Protein DDI1 homolog 1	DEG_SPOP_SBC_1	102:106	PGTSS	SPOP	0.9889	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7738:7742	PGTSS	SPOP	0.9963	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8317:8321	PGTSS	SPOP	0.9624	More...
Q96G74	OTU domain-containing protein 5	DEG_SPOP_SBC_1	493:497	PGTSS	SPOP	0.9984	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	296:300	PGTSS	SPOP	0.9951	More...
Q96PY5	Formin-like protein 2	DEG_SPOP_SBC_1	598:602	PGTSS	SPOP	0.9832	More...
Q96RE7	Nucleus accumbens-associated protein 1	DEG_SPOP_SBC_1	264:268	PGTSS	SPOP	0.9975	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	864:868	PGTSS	SPOP	0.9926	More...
Q9HB58	Sp110 nuclear body protein	DEG_SPOP_SBC_1	159:163	PGTSS	SPOP	0.9408	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	372:376	PGTSS	SPOP	0.9983	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	637:641	PGTSS	SPOP	0.9454	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	599:603	PGTSS	SPOP	0.5271	More...
Q9UIB8	SLAM family member 5	DEG_SPOP_SBC_1	336:340	PGTSS	SPOP	0.9897	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	963:967	PGTSS	SPOP	0.9939	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	418:422	PGTSS	SPOP	0.9951	More...
Q96SC8	Doublesex- and mab-3-related transcription factor A2	DEG_SPOP_SBC_1	226:230	PGTSS	SPOP	0.824	More...
Q8NGY2	Olfactory receptor 6K2	DEG_SPOP_SBC_1	317:321	PGTSS	SPOP	0.8496	More...
Q96IM9	DPY30 domain-containing protein 2	DEG_SPOP_SBC_1	123:127	PGTSS	SPOP	0.9785	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	454:458	PGTSS	SPOP	0.9051	More...
Q6IPT2	Golgi associated RAB2 interactor protein 5A	DEG_SPOP_SBC_1	15:19	PGTSS	SPOP	0.9651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTSS

Degron related mutations and impact score

Drug responses associated with APC mutations

All proteins holding degron of PGTSS