DegronMD - Q8IWN7(RP1L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T24N	TCGA-13-0885	OV	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.8166
p.T24N	DO30490	OV	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.8166
p.A33D	TCGA-17-Z042	LUAD	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1944
p.A33D	TCGA-AA-3977	COAD	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1944
p.A33D	DO8730	COAD	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1944
p.P302L	TCGA-2W-A8YY	CESC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.P302L	DO223732	CESC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.P302L	SIDM01752	Pancreatic Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.P302L	ACH-000685	Pancreatic Cancer	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.T1083K	TCGA-39-5021	LUSC	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.1389
p.T1083K	DO27397	LUSC	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.1389
p.E2346D	TCGA-39-5036	LUSC	TCGA	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation altering degron motif	0.5647
p.E2346D	DO27508	LUSC	ICGC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation altering degron motif	0.5647
p.Y2344C	TCGA-3G-AB0T	THYM	TCGA	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.3056
p.P2273T	TCGA-44-7670	LUAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.2222
p.P2273T	DO23555	LUAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.2222
p.E2229K	TCGA-55-6712	LUAD	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.591
p.E2229K	DO25310	LUAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.591
p.R1073L	TCGA-55-7574	LUAD	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7316
p.R1073L	DO23986	LUAD	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7316
p.G1077C	TCGA-55-7576	LUAD	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.3056
p.G1077C	DO24431	LUAD	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.3056
p.T296M	TCGA-55-7727	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7423
p.T296M	DO234149	ESAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7423
p.T296M	DO233119	GACA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7423
p.T296M	DO24297	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7423
p.P289T	TCGA-55-7913	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.P289T	DO223665	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2222
p.D308V	TCGA-55-8092	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.D308V	DO26220	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.E2240D	TCGA-64-5779	LUAD	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240D	DO24930	LUAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.D307N	TCGA-66-2742	LUSC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.D307N	TCGA-ER-A2NE	SKCM	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.D307N	DO26439	LUSC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.D307N	DO48663	SKCM	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1389
p.P2283Q	TCGA-69-7974	LUAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.3056
p.P2283Q	DO23850	LUAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.3056
p.E15D	TCGA-78-7542	LUAD	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1667
p.E15D	DO24760	LUAD	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1667
p.P283T	TCGA-85-8350	LUSC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P283T	DO45492	LUSC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P287T	TCGA-91-8499	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667
p.P287T	DO45349	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667
p.L148F	TCGA-A5-A0G1	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.L148F	DO42472	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.R1078Q	TCGA-A5-A0GW	UCEC	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.2778
p.R1078Q	DO41103	UCEC	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.2778
p.P2277H	TCGA-AA-3833	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.7694
p.P2277H	DO9796	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.7694
p.P2277S	TCGA-AA-3864	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.6752
p.P2277S	DO8490	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.6752
p.S300L	TCGA-AA-A010	COAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7667
p.S300L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation altering degron motif	0.7667
p.T31M	TCGA-AJ-A3OK	UCEC	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.25
p.T31M	DO43602	UCEC	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.25
p.R2276M	TCGA-AP-A059	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.3056
p.R2276M	DO41361	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.3056
p.E2236D	TCGA-AP-A059	UCEC	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.2778
p.E2236D	DO41361	UCEC	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.2778
p.G140D	TCGA-AP-A059	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.6087
p.G140D	DO41361	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.6087
p.A2233T	TCGA-AP-A1DV	UCEC	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.6028
p.A2233T	DO43186	UCEC	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.6028
p.P283L	TCGA-AX-A1CE	UCEC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.P283L	DO42280	UCEC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.H1187N	TCGA-BQ-7044	KIRP	TCGA	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1111
p.H1187N	DO20942	KIRP	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1111
p.A2355T	TCGA-BR-4184	STAD	TCGA	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1667
p.A2355T	DO38328	STAD	ICGC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1667
p.E133K	TCGA-CN-4734	HNSC	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.E133K	DO233877	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.E133K	DO15446	HNSC	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.E1191D	TCGA-CN-4739	HNSC	TCGA	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.E1191D	DO222884	COCA	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.E1191D	DO14478	HNSC	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.E137K	TCGA-D3-A3MR	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.E137K	TCGA-FW-A3R5	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.E137K	DO47256	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.E137K	DO37406	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.E2337K	TCGA-DA-A1IC	SKCM	TCGA	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1111
p.E2337K	DO37430	SKCM	ICGC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1111
p.R152Q	TCGA-DI-A1BU	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R152Q	DO42023	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R152Q	SIDM00373	Endometrial Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.M309T	TCGA-DU-7304	LGG	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.M309T	DO22397	LGG	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P11L	TCGA-EE-A29D	SKCM	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.P11L	DO38123	SKCM	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.P11L	SIDM00600	Thyroid Gland Carcinoma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.P11L	SIDM00368	Small Cell Lung Carcinoma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.P11L	SIDM00720	Mesothelioma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.P11L	SIDM01460	Glioma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0556
p.P2288L	TCGA-EE-A2GJ	SKCM	TCGA	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.P2288L	DO37746	SKCM	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.E1191K	TCGA-EE-A2GJ	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.E1191K	DO37746	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.P462S	TCGA-EE-A3AE	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.P462S	DO37802	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.P2231L	TCGA-EJ-5525	PRAD	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.7582
p.P2231L	DO36340	PRAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.7582
p.K310N	TCGA-EO-A3B0	UCEC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation substituting flanking lysine	0.1667
p.K310N	DO219773	UCEC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation substituting flanking lysine	0.1667
p.P151L	TCGA-ER-A193	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.P151L	DO47368	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R291M	TCGA-ER-A19P	SKCM	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.R291M	DO47623	SKCM	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.2778
p.E466Q	TCGA-EY-A54A	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.E466Q	DO48175	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.R1073W	TCGA-FI-A2D4	UCEC	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7523
p.R1073W	DO43170	UCEC	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7523
p.G2243R	TCGA-FW-A3R5	SKCM	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.0833
p.G2243R	DO37406	SKCM	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.0833
p.P467S	TCGA-GN-A26C	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.P467S	DO37782	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.P455S	TCGA-HU-8602	STAD	TCGA	PASST	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.6752
p.P455S	DO47829	STAD	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.6752
p.S26L	TCGA-JW-A5VJ	CESC	TCGA	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.6556
p.S26L	DO49974	CESC	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.6556
p.R130L	TCGA-L9-A7SV	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130L	DO49875	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130L	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130L	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130L	ACH-000590	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130L	ACH-001137	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130L	NCI-H1993	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.Q135R	TCGA-MX-A5UJ	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.Q135R	DO48547	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.V2228I	TCGA-QH-A6CZ	LGG	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.V2228I	DO50173	LGG	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.V2228I	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.V2228I	SIDM00790	Non-Cancerous	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.V2228I	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.V2228I	ACH-000795	Leukemia	CCLE	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.V2228I	ACH-002371	Non-Cancerous	CCLE	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.5965
p.G1209D	TCGA-SR-A6MP	PCPG	TCGA	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.0556
p.G460S	TCGA-UF-A71B	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.G460S	DO52107	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.3056
p.S469F	TCGA-W3-A828	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.S469F	DO220890	MELA	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.S469F	DO51273	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.E2219G	TCGA-Z6-A8JE	ESCA	TCGA	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.0833
p.E2219G	DO228271	MALY	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.0833
p.S2241L	DO222467	BTCA	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1389
p.S2241L	DO218693	GACA	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1389
p.G2285R	DO222990	BTCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.25
p.G2285R	DO229013	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.25
p.G2285R	DO229016	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.25
p.G2285R	DO229005	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.25
p.T37A	DO222755	COCA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.0833
p.R136H	DO222765	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.R136H	DO51507	PACA	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.T28N	DO222778	COCA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.7055
p.T2230A	DO50323	ESAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation altering degron motif	0.7139
p.T1194M	DO234250	ESAD	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.3056
p.T150P	DO234303	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389
p.T150P	DO51478	PACA	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389
p.R136C	DO234453	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.A1074T	DO228581	GACA	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.6028
p.Q135K	DO228732	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.G1206S	DO233254	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1389
p.A1060V	DO233765	GACA	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.1111
p.R14C	DO233869	GACA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.1389
p.R2342G	DO233913	GACA	ICGC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.25
p.I1085M	DO229346	LAML	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00435	Acute Myeloid Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00608	Plasma Cell Myeloma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00572	Gastric Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00293	Small Cell Lung Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00060	Ovarian Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00252	Biliary Tract Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM01471	Chronic Myelogenous Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM00163	Biliary Tract Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM01451	Pancreatic Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.I1085M	SIDM01618	B-Lymphoblastic Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0833
p.A1188D	DO229038	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1389
p.H292Y	DO50970	LICA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.S1198F	DO220877	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation altering degron motif	0.7982
p.E466K	DO220911	MELA	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.P2279L	DO222702	MELA	ICGC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.7582
p.G290S	DO222868	MELA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.25
p.A1058G	DO52129	PAEN	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.K35M	DO229459	SKCA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation substituting flanking lysine	0.25
p.Q450R	DO229275	THCA	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.E463Q	DO229221	THCA	ICGC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.P1195H	SIDM02050	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation altering degron motif	0.7694
p.R145Q	SIDM02043	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.P19H	SIDM02021	Esophageal Carcinoma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation rewiring degron network	0.2778
p.P2271R	SIDM00985	Burkitt's Lymphoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.P2271R	SIDM00258	Neuroblastoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.P2271R	SIDM00127	Oral Cavity Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.P2271R	SIDM01055	Glioblastoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.P2271R	SIDM00983	Bladder Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.P2271R	SIDM00182	Head and Neck Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM00672	Hepatocellular Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM01147	Gastric Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM00863	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM00808	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM00628	Breast Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM01409	Bladder Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.E2240Q	SIDM01254	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.M1086I	SIDM00608	Plasma Cell Myeloma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.M1086I	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.M1086I	ACH-000309	Lung Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.M1086I	ACH-000714	Myeloma	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.M1086I	SK-LU-1	lung	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.M1086I	KMS-11	haematopoietic and lymphoid tissue	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.0556
p.P2225L	SIDM00672	Hepatocellular Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM01147	Gastric Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM00863	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM00808	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM00628	Breast Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM01409	Bladder Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.P2225L	SIDM01254	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.25
p.G1067A	SIDM00127	Oral Cavity Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.3056
p.G1067A	JHU-022	upper aerodigestive tract	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.3056
p.R1078W	SIDM00157	Neuroblastoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.2778
p.R1078W	KP-N-YS	autonomic ganglia	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.2778
p.P284A	SIDM00846	Cervical Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P284A	SIDM00257	Neuroblastoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P284A	SIDM01752	Pancreatic Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.G464S	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.G464S	ACH-000605	Esophageal Cancer	CCLE	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.G464S	TE-6	oesophagus	COSMIC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.P284L	SIDM00529	Breast Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P284L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.P284L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.S2282F	SIDM00650	Small Cell Lung Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.7982
p.S2282F	SIDM01681	Non-Cancerous	GDSC	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation altering degron motif	0.7982
p.R130W	SIDM01100	Neuroblastoma	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130W	ACH-000366	Neuroblastoma	CCLE	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130W	SK-N-DZ	autonomic ganglia	COSMIC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.S457C	SIDM00332	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7541
p.S457C	ACH-001819	Breast Cancer	CCLE	PASST	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7541
p.S457C	MFM-223	breast	COSMIC	PASST	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7541
p.A1081T	SIDM00487	Colorectal Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.1944
p.A1081T	ACH-000963	Colon/Colorectal Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.1944
p.A1081T	CCK-81	large intestine	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.1944
p.E2337G	SIDM00489	Oral Cavity Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1111
p.E2337G	ACH-002043	Head and Neck Cancer	CCLE	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1111
p.E2337G	Ca9-22	upper aerodigestive tract	COSMIC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1111
p.R2342M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.25
p.R2342M	ACH-000826	Lung Cancer	CCLE	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.25
p.R2342M	CAL-12T	lung	COSMIC	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.25
p.S449R	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.S449R	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.S449R	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.S449R	ACH-000681	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.S449R	ACH-002337	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.S449R	A549	lung	COSMIC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.D308N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.D308N	ACH-000945	Lung Cancer	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.D308N	NCI-H650	lung	COSMIC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.G1185E	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.0556
p.G1185E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.0556
p.D131N	SIDM00140	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.D131N	ACH-000968	Skin Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.D131N	COLO-792	skin	COSMIC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.V1079A	SIDM00537	Colorectal Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.25
p.V1079A	ACH-001345	Colon/Colorectal Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.25
p.V1079A	GP5d	large intestine	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation rewiring degron network	0.25
p.R1069S	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7427
p.R1069S	ACH-000596	Lung Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7427
p.R1069S	LCLC-97TM1	lung	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	1068:1076	Mutation altering degron motif	0.7427
p.R130Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130Q	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.Q450H	SIDM00901	Endometrial Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.Q450H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.Q450H	AN3-CA	endometrium	COSMIC	PASST	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.Q2222L	SIDM01608	Endometrial Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.Q2222L	ACH-000990	Endometrial/Uterine Cancer	CCLE	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.1667
p.V285M	SIDM01577	Plasma Cell Myeloma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.V285M	ACH-000889	Myeloma	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1111
p.A138T	ACH-000123	Ovarian Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.3056
p.E2354A	ACH-000982	Colon/Colorectal Cancer	CCLE	PESST	DEG_SPOP_SBC_1	2345:2349	Mutation rewiring degron network	0.1944
p.T24S	ACH-001270	Sarcoma	CCLE	VARTPSVT	DEG_SCF_FBW7_1	21:28	Mutation altering degron motif	0.8227
p.P2292S	ACH-001275	Sarcoma	CCLE	PTPPPS	DEG_SCF_FBW7_1	2277:2282	Mutation rewiring degron network	0.0556
p.T459N	ACH-001366	Neuroblastoma	CCLE	PASST	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.7055
p.E2226Q	ACH-002039	Pancreatic Cancer	CCLE	VETPEAE	DEG_SCF_FBW7_2	2228:2234	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RP1L1

UniProt ID: Q8IWN7

Entrez ID: 94137

Protein name: Retinitis pigmentosa 1-like 1 protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RP1L1 in