DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SCF_FBW7_1

Location: 293:300

E3 ligase: FBXW7

DEGRON score: 0.8409

ASA_SCORE: 76.075

COIL: 0.849

CONS_SCORE: 0.4145

DSS_SCORE: 0.8473

HELIX: 0.0978

FCONS_SCORE: 0.7796

RIG_SCORE: 0.567

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P302L	TCGA-2W-A8YY	CESC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.P302L	DO223732	CESC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.P302L	SIDM01752	Pancreatic Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.P302L	ACH-000685	Pancreatic Cancer	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.T296M	TCGA-55-7727	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.T296M	DO234149	ESAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.T296M	DO233119	GACA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.T296M	DO24297	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.P289T	TCGA-55-7913	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.2222
p.P289T	DO223665	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.2222
p.D308V	TCGA-55-8092	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1111
p.D308V	DO26220	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1111
p.D307N	TCGA-66-2742	LUSC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D307N	TCGA-ER-A2NE	SKCM	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D307N	DO26439	LUSC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D307N	DO48663	SKCM	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.P283T	TCGA-85-8350	LUSC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.0556
p.P283T	DO45492	LUSC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.0556
p.P287T	TCGA-91-8499	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.P287T	DO45349	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.S300L	TCGA-AA-A010	COAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.7667
p.S300L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.7667
p.P283L	TCGA-AX-A1CE	UCEC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.0556
p.P283L	DO42280	UCEC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.0556
p.M309T	TCGA-DU-7304	LGG	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.M309T	DO22397	LGG	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.K310N	TCGA-EO-A3B0	UCEC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.K310N	DO219773	UCEC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.R291M	TCGA-ER-A19P	SKCM	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.R291M	DO47623	SKCM	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.H292Y	DO50970	LICA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.3056
p.G290S	DO222868	MELA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.25
p.P284A	SIDM00846	Cervical Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.P284A	SIDM00257	Neuroblastoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.P284A	SIDM01752	Pancreatic Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.P284L	SIDM00529	Breast Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.P284L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.P284L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.0833
p.D308N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.1111
p.D308N	ACH-000945	Lung Cancer	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	0.1111
p.D308N	NCI-H650	lung	COSMIC	PQDTPAQS	DEG_SCF_FBW7_1	0.1111
p.V285M	SIDM01577	Plasma Cell Myeloma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.1111
p.V285M	ACH-000889	Myeloma	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQDTPAQS

Degron related mutations and impact score

Drug responses associated with RP1L1 mutations

All proteins holding degron of PQDTPAQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	293:300	PQDTPAQS	FBXW7	0.8409	More...