DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SCF_FBW7_1

Location: 293:300

E3 ligase: FBXW7

DEGRON score: 0.8409

ASA_SCORE: 76.075

COIL: 0.849

CONS_SCORE: 0.4145

DSS_SCORE: 0.8473

HELIX: 0.0978

FCONS_SCORE: 0.7796

RIG_SCORE: 0.567

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S300L	TCGA-AA-A010	COAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.7667
p.S300L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.7667
p.T296M	TCGA-55-7727	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.T296M	DO234149	ESAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.T296M	DO233119	GACA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.T296M	DO24297	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.7423
p.H292Y	DO50970	LICA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.3056
p.P302L	TCGA-2W-A8YY	CESC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.P302L	DO223732	CESC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.P302L	SIDM01752	Pancreatic Carcinoma	GDSC	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.P302L	ACH-000685	Pancreatic Cancer	CCLE	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.R291M	TCGA-ER-A19P	SKCM	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.R291M	DO47623	SKCM	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.2778
p.G290S	DO222868	MELA	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.25
p.P289T	TCGA-55-7913	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.2222
p.P289T	DO223665	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.2222
p.P287T	TCGA-91-8499	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.P287T	DO45349	LUAD	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.K310N	TCGA-EO-A3B0	UCEC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.K310N	DO219773	UCEC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1667
p.D307N	TCGA-66-2742	LUSC	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D307N	TCGA-ER-A2NE	SKCM	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D307N	DO26439	LUSC	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D307N	DO48663	SKCM	ICGC	PQDTPAQS	DEG_SCF_FBW7_1	0.1389
p.D308V	TCGA-55-8092	LUAD	TCGA	PQDTPAQS	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	293:300	PQDTPAQS	FBXW7	0.8409	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons