DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SPOP_SBC_1

Location: 1195:1199

E3 ligase: SPOP

DEGRON score: 0.9915

ASA_SCORE: 60.44

COIL: 0.866

CONS_SCORE: 0.7856

DSS_SCORE: 0.5594

HELIX: 0.0452

FCONS_SCORE: 1.4271

RIG_SCORE: 0.6484

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1198F	DO220877	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7982
p.P1195H	SIDM02050	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.7694
p.T1194M	DO234250	ESAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.3056
p.E1191D	TCGA-CN-4739	HNSC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.2222
p.E1191D	DO222884	COCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.E1191D	DO14478	HNSC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.E1191K	TCGA-EE-A2GJ	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	0.2222
p.E1191K	DO37746	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.G1206S	DO233254	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1389
p.A1188D	DO229038	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1389
p.H1187N	TCGA-BQ-7044	KIRP	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1111
p.H1187N	DO20942	KIRP	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1111
p.G1209D	TCGA-SR-A6MP	PCPG	TCGA	PTSSS	DEG_SPOP_SBC_1	0.0556
p.G1185E	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.0556
p.G1185E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 15 of 15 entries

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Drug responses associated with RP1L1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PTSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	DEG_SPOP_SBC_1	470:474	PTSSS	SPOP	0.9605	More...
Q05823	2-5A-dependent ribonuclease	DEG_SPOP_SBC_1	13:17	PTSSS	SPOP	0.9874	More...
Q4VCS5	Angiomotin	DEG_SPOP_SBC_1	211:215	PTSSS	SPOP	0.9988	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2626:2630	PTSSS	SPOP	0.9845	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	139:143	PTSSS	SPOP	0.948	More...
Q92934	Bcl2-associated agonist of cell death	DEG_SPOP_SBC_1	55:59	PTSSS	SPOP	0.7818	More...
Q9BUH8	Brain-enriched guanylate kinase-associated protein	DEG_SPOP_SBC_1	295:299	PTSSS	SPOP	0.9553	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	17:21	PTSSS	SPOP	0.8669	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	2379:2383	PTSSS	SPOP	0.9083	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1276:1280	PTSSS	SPOP	0.9503	More...
P50402	Emerin	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.9908	More...
O15353	Forkhead box protein N1	DEG_SPOP_SBC_1	566:570	PTSSS	SPOP	0.9933	More...
Q9Y5N1	Histamine H3 receptor	DEG_SPOP_SBC_1	303:307	PTSSS	SPOP	0.9912	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1874:1878	PTSSS	SPOP	0.8129	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	657:661	PTSSS	SPOP	0.9681	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	306:310	PTSSS	SPOP	0.9982	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	377:381	PTSSS	SPOP	0.9915	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SPOP_SBC_1	166:170	PTSSS	SPOP	0.9809	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	135:139	PTSSS	SPOP	0.9984	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	923:927	PTSSS	SPOP	0.9994	More...
O14795	Protein unc-13 homolog B	DEG_SPOP_SBC_1	255:259	PTSSS	SPOP	0.9982	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	742:746	PTSSS	SPOP	0.9157	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	1195:1199	PTSSS	SPOP	0.9915	More...
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SPOP_SBC_1	314:318	PTSSS	SPOP	0.9747	More...
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	833:837	PTSSS	SPOP	0.988	More...

Showing 1 to 25 of 32 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSSS

Degron related mutations and impact score

Drug responses associated with RP1L1 mutations

All proteins holding degron of PTSSS