DegronMD

Uniprot ID: Q4VCS5

Source protein: Angiomotin

Source gene: AMOT

Class: DEG_SPOP_SBC_1

Location: 211:215

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 75.58

COIL: 0.8438

CONS_SCORE: 0.4119

DSS_SCORE: 0.6662

HELIX: 0.129

FCONS_SCORE: 1.0632

RIG_SCORE: 0.6208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T212K	TCGA-AR-A1AR	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.6195
p.T212K	DO4893	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.6195
p.D206Y	TCGA-B5-A1MR	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206Y	DO41758	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.T212A	TCGA-CA-6717	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	0.6028
p.T212A	DO8264	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.6028
p.S213C	TCGA-EO-A2CG	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.7541
p.S213C	DO42185	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7541
p.P225S	TCGA-UC-A7PG	CESC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.0556
p.P225S	DO51615	CESC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.0556
p.R217H	DO219908	DLBC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2778
p.R219W	DO233903	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.6667
p.R224K	DO218923	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.0833
p.E216K	DO218850	SKCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.3056
p.S213I	DO234002	THCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7341
p.A220V	DO41199	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.A220T	SIDM01057	Acute Myeloid Leukemia	GDSC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.A220T	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206N	SIDM00590	Oral Cavity Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206N	SIDM00124	Kidney Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206N	ACH-000472	Head and Neck Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206N	ACH-000555	Kidney Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206N	A498	kidney	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.D206N	HSC-2	upper_aerodigestive_tract	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.S215I	ACH-000127	Bladder Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.7341
p.E212K	MCC13	skin	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.7022
p.L201I	A253	salivary_gland	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	833:837	PTSSS	SPOP	0.988	More...
O14795	Protein unc-13 homolog B	DEG_SPOP_SBC_1	255:259	PTSSS	SPOP	0.9982	More...
O15353	Forkhead box protein N1	DEG_SPOP_SBC_1	566:570	PTSSS	SPOP	0.9933	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	135:139	PTSSS	SPOP	0.9984	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	306:310	PTSSS	SPOP	0.9982	More...
P50402	Emerin	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.9908	More...
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	DEG_SPOP_SBC_1	470:474	PTSSS	SPOP	0.9605	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.896	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1874:1878	PTSSS	SPOP	0.8129	More...
Q05823	2-5A-dependent ribonuclease	DEG_SPOP_SBC_1	13:17	PTSSS	SPOP	0.9874	More...
Q10571	Transcriptional activator MN1	DEG_SPOP_SBC_1	1138:1142	PTSSS	SPOP	0.9495	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2626:2630	PTSSS	SPOP	0.9845	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	2377:2381	PTSSS	SPOP	0.9821	More...
Q2QGD7	Zinc finger protein ZXDC	DEG_SPOP_SBC_1	640:644	PTSSS	SPOP	0.9976	More...
Q4VCS5	Angiomotin	DEG_SPOP_SBC_1	211:215	PTSSS	SPOP	0.9988	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1276:1280	PTSSS	SPOP	0.9503	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	742:746	PTSSS	SPOP	0.9157	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1268:1272	PTSSS	SPOP	0.9958	More...
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SPOP_SBC_1	314:318	PTSSS	SPOP	0.9747	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	377:381	PTSSS	SPOP	0.9915	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SPOP_SBC_1	166:170	PTSSS	SPOP	0.9809	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	1195:1199	PTSSS	SPOP	0.9915	More...
Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	DEG_SPOP_SBC_1	392:396	PTSSS	SPOP	0.6471	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	139:143	PTSSS	SPOP	0.948	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	923:927	PTSSS	SPOP	0.9994	More...
Q92934	Bcl2-associated agonist of cell death	DEG_SPOP_SBC_1	55:59	PTSSS	SPOP	0.7818	More...
Q9BUH8	Brain-enriched guanylate kinase-associated protein	DEG_SPOP_SBC_1	295:299	PTSSS	SPOP	0.9553	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	2319:2323	PTSSS	SPOP	0.9971	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	2379:2383	PTSSS	SPOP	0.9083	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	17:21	PTSSS	SPOP	0.8669	More...
Q9Y5N1	Histamine H3 receptor	DEG_SPOP_SBC_1	303:307	PTSSS	SPOP	0.9912	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	657:661	PTSSS	SPOP	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSSS

Degron related mutations and impact score

Drug responses associated with AMOT mutations

All proteins holding degron of PTSSS