DegronMD - Q00722(PLCB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W809C	TCGA-AA-3986	COAD	TCGA	LFIFLE	LIG_APCC_ABBA_1	795:800	Mutation rewiring degron network	0.0833
p.Q466P	TCGA-AZ-4315	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2222
p.Q466P	DO8842	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2222
p.N462S	TCGA-D1-A17Q	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1111
p.N462S	DO41903	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1111
p.K463R	TCGA-D8-A73W	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation substituting flanking lysine	0.25
p.K463R	DO219631	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation substituting flanking lysine	0.25
p.G479V	TCGA-FS-A1Z0	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1944
p.G479V	DO37431	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1944
p.G483C	TCGA-J2-A4AD	LUAD	TCGA	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.0833
p.G483C	DO23915	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.0833
p.W805C	DO8216	COAD	ICGC	LFIFLE	LIG_APCC_ABBA_1	795:800	Mutation rewiring degron network	0.1944
p.T471N	DO229022	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.5944
p.T787I	DO50970	LICA	ICGC	LFIFLE	LIG_APCC_ABBA_1	795:800	Mutation rewiring degron network	0.1111
p.G479R	DO222402	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1944
p.T471S	DO232838	NACA	ICGC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.6005
p.D476N	SIDM00545	Melanoma	GDSC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2778
p.D476N	ACH-000987	Skin Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2778
p.D476N	Mewo	skin	COSMIC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2778
p.T471I	SIDM00808	Burkitt's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.5966
p.T471I	SIDM01409	Bladder Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.5966
p.T471I	SIDM01254	Burkitt's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.5966
p.N465I	SIDM01443	Gastric Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1944
p.N465I	ACH-000344	Gastric Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1944

Kaplan plot for PLCB2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCB2

UniProt ID: Q00722

Entrez ID: 5330

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PLCB2 in