DegronMD

Uniprot ID: Q00722

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Source gene: PLCB2

Class: LIG_APCC_ABBA_1

Location: 795:800

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5049

ASA_SCORE: 23.1

COIL: 0.0423

CONS_SCORE: 0.4801

DSS_SCORE: 0.0152

HELIX: 0.0052

FCONS_SCORE: 1.2413

RIG_SCORE: 0.9847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W809C	TCGA-AA-3986	COAD	TCGA	LFIFLE	LIG_APCC_ABBA_1	0.0833
p.W805C	DO8216	COAD	ICGC	LFIFLE	LIG_APCC_ABBA_1	0.1944
p.T787I	DO50970	LICA	ICGC	LFIFLE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	LIG_APCC_ABBA_1	795:800	LFIFLE	APC,CDC20,FZR1	0.5049	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons