DegronMD - O14795(UNC13B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S212F	TCGA-A5-A1OF	UCEC	TCGA	PPPY	ITCH	200:203	Mutation rewiring degron network	0.0833
p.S212F	DO42568	UCEC	ICGC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.0833
p.A211T	TCGA-AX-A1CE	UCEC	TCGA	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.A211T	TCGA-CK-4951	COAD	TCGA	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.A211T	DO10582	COAD	ICGC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.A211T	DO42280	UCEC	ICGC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.R250Q	TCGA-B7-5818	STAD	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1944
p.R250Q	DO38883	STAD	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1944
p.S257R	TCGA-CA-6717	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7427
p.S257R	DO8264	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7427
p.S196N	TCGA-DF-A2KU	UCEC	TCGA	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S196N	DO223286	UCEC	ICGC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.R251Q	TCGA-DF-A2KU	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.R251Q	DO223286	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.S259G	TCGA-DI-A1BU	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6993
p.S259G	DO42023	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6993
p.S263F	TCGA-DK-A2I4	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.S263F	DO48451	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.S263F	DO465	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.S263F	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.S263F	ACH-000914	Lymphoma	CCLE	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.S263F	HT	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2222
p.P248S	TCGA-EE-A29E	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.P248S	DO37831	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.H204N	TCGA-EE-A3AD	SKCM	TCGA	PPPY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.H204N	DO37707	SKCM	ICGC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.Y203C	TCGA-EO-A22R	UCEC	TCGA	PPPY	ITCH	200:203	Mutation altering degron motif	0.7087
p.Y203C	DO42713	UCEC	ICGC	PPPY	ITCH	200:203	Mutation altering degron motif	0.7087
p.R250W	TCGA-EO-A22U	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1944
p.R250W	DO43755	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1944
p.R250W	ACH-001369	Ovarian Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1944
p.T205I	DO52438	COCA	ICGC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2778
p.P202A	DO50403	ESAD	ICGC	PPPY	ITCH	200:203	Mutation altering degron motif	0.6392
p.V267L	DO229029	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.S257N	DO230993	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7069
p.P248L	DO230449	UTCA	ICGC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.S198I	SIDM01943	Colorectal Carcinoma	GDSC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2778
p.S196T	SIDM00798	Rhabdomyosarcoma	GDSC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S196T	ACH-000201	Rhabdoid	CCLE	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S196T	ACH-001212	Rhabdoid	CCLE	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S196T	A204	soft tissue	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S207F	SIDM00392	Melanoma	GDSC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S207F	ACH-000810	Skin Cancer	CCLE	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S207F	SK-MEL-30	skin	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.R260G	SIDM00487	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.3056
p.R260G	ACH-000963	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.3056
p.R260G	CCK-81	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.3056
p.R192C	SIDM00560	Gastric Carcinoma	GDSC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.R192C	ACH-000167	Myeloma	CCLE	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.R192C	ACH-000678	Gastric Cancer	CCLE	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.R192C	MKN7	stomach	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.D191E	JHU-022	upper aerodigestive tract	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.0833
p.R199G	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.R199G	SNU-398	liver	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.3056
p.S208T	A204	soft tissue	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.1944
p.R252C	SNU-1040	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.25
p.R204C	MKN7	stomach	COSMIC	PPPY	ITCH	200:203	Mutation rewiring degron network	0.3056

Kaplan plot for UNC13B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC13B

UniProt ID: O14795

Entrez ID: 10497

Protein name: Protein unc-13 homolog B (Munc13-2) (munc13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC13B in