DegronMD

Uniprot ID: O14795

Source protein: Protein unc-13 homolog B

Source gene: UNC13B

Class: DEG_SPOP_SBC_1

Location: 255:259

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 66.42

COIL: 0.8636

CONS_SCORE: 0.3912

DSS_SCORE: 0.5666

HELIX: 0.0686

FCONS_SCORE: 1.1363

RIG_SCORE: 0.6056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R250Q	TCGA-B7-5818	STAD	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1944
p.R250Q	DO38883	STAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.S257R	TCGA-CA-6717	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	0.7427
p.S257R	DO8264	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7427
p.R251Q	TCGA-DF-A2KU	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.2222
p.R251Q	DO223286	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.S259G	TCGA-DI-A1BU	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.6993
p.S259G	DO42023	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.6993
p.S263F	TCGA-DK-A2I4	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.2222
p.S263F	DO48451	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.S263F	DO465	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.S263F	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.S263F	ACH-000914	Lymphoma	CCLE	PTSSS	DEG_SPOP_SBC_1	0.2222
p.S263F	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.P248S	TCGA-EE-A29E	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1389
p.P248S	DO37831	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1389
p.R250W	TCGA-EO-A22U	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1944
p.R250W	DO43755	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1944
p.R250W	ACH-001369	Ovarian Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.1944
p.V267L	DO229029	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1111
p.S257N	DO230993	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7069
p.P248L	DO230449	UTCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1389
p.R260G	SIDM00487	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.3056
p.R260G	ACH-000963	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.3056
p.R260G	CCK-81	large_intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.3056
p.R252C	SNU-1040	large_intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	833:837	PTSSS	SPOP	0.988	More...
O14795	Protein unc-13 homolog B	DEG_SPOP_SBC_1	255:259	PTSSS	SPOP	0.9982	More...
O15353	Forkhead box protein N1	DEG_SPOP_SBC_1	566:570	PTSSS	SPOP	0.9933	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	135:139	PTSSS	SPOP	0.9984	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	306:310	PTSSS	SPOP	0.9982	More...
P50402	Emerin	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.9908	More...
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	DEG_SPOP_SBC_1	470:474	PTSSS	SPOP	0.9605	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.896	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1874:1878	PTSSS	SPOP	0.8129	More...
Q05823	2-5A-dependent ribonuclease	DEG_SPOP_SBC_1	13:17	PTSSS	SPOP	0.9874	More...
Q10571	Transcriptional activator MN1	DEG_SPOP_SBC_1	1138:1142	PTSSS	SPOP	0.9495	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2626:2630	PTSSS	SPOP	0.9845	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	2377:2381	PTSSS	SPOP	0.9821	More...
Q2QGD7	Zinc finger protein ZXDC	DEG_SPOP_SBC_1	640:644	PTSSS	SPOP	0.9976	More...
Q4VCS5	Angiomotin	DEG_SPOP_SBC_1	211:215	PTSSS	SPOP	0.9988	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1276:1280	PTSSS	SPOP	0.9503	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	742:746	PTSSS	SPOP	0.9157	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1268:1272	PTSSS	SPOP	0.9958	More...
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SPOP_SBC_1	314:318	PTSSS	SPOP	0.9747	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	377:381	PTSSS	SPOP	0.9915	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SPOP_SBC_1	166:170	PTSSS	SPOP	0.9809	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	1195:1199	PTSSS	SPOP	0.9915	More...
Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	DEG_SPOP_SBC_1	392:396	PTSSS	SPOP	0.6471	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	139:143	PTSSS	SPOP	0.948	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	923:927	PTSSS	SPOP	0.9994	More...
Q92934	Bcl2-associated agonist of cell death	DEG_SPOP_SBC_1	55:59	PTSSS	SPOP	0.7818	More...
Q9BUH8	Brain-enriched guanylate kinase-associated protein	DEG_SPOP_SBC_1	295:299	PTSSS	SPOP	0.9553	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	2319:2323	PTSSS	SPOP	0.9971	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	2379:2383	PTSSS	SPOP	0.9083	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	17:21	PTSSS	SPOP	0.8669	More...
Q9Y5N1	Histamine H3 receptor	DEG_SPOP_SBC_1	303:307	PTSSS	SPOP	0.9912	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	657:661	PTSSS	SPOP	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSSS

Degron related mutations and impact score

Drug responses associated with UNC13B mutations

All proteins holding degron of PTSSS