DegronMD - Q86YN6(PPARGC1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S832C	TCGA-05-4250	LUAD	TCGA	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2778
p.S832C	DO24457	LUAD	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2778
p.D819Y	TCGA-A8-A0A7	BRCA	TCGA	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.1944
p.R180C	TCGA-AJ-A3OJ	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.R180C	TCGA-DJ-A3V5	THCA	TCGA	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.R180C	DO40508	THCA	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.R180C	DO42753	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.G600D	TCGA-B5-A3FA	UCEC	TCGA	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.2222
p.G600D	DO52402	UCEC	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.2222
p.L805F	TCGA-BF-AAP6	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.2222
p.L805F	DO219470	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.2222
p.E787K	TCGA-CF-A47X	BLCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.0833
p.D833N	TCGA-DD-AACU	LIHC	TCGA	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.25
p.P607L	TCGA-GU-A42Q	BLCA	TCGA	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation altering degron motif	0.6471
p.P607L	DO485	BLCA	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation altering degron motif	0.6471
p.A178T	TCGA-IB-7651	PAAD	TCGA	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.A178T	DO46657	PAAD	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.R597Q	DO222804	COCA	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.1389
p.R597Q	DO36531	READ	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.1389
p.R597Q	IGROV-1	ovary	COSMIC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.1389
p.G167S	DO234304	ESAD	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.6993
p.A607T	DO228542	GACA	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation altering degron motif	0.7139
p.A607T	DO48032	STAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation altering degron motif	0.7139
p.A826T	DO233731	GACA	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation altering degron motif	0.7139
p.R619H	DO10880	GBM	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.0556
p.R619H	DO26015	LUAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.0556
p.R619H	DO46657	PAAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.0556
p.R830W	DO14067	GBM	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation altering degron motif	0.8634
p.R830W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation altering degron motif	0.8634
p.R830W	NCI-SNU-1	stomach	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation altering degron motif	0.8634
p.R180L	DO228971	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.R180L	DO227661	PACA	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.A180S	DO229034	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.A159T	DO229177	LMS	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1389
p.T159S	DO25787	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1389
p.S817L	DO220851	MELA	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.1389
p.H594R	DO228019	SKCA	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.0556
p.H603Y	DO37567	SKCM	ICGC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.3056
p.S169A	DO40884	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7588
p.T820M	DO42713	UCEC	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2222
p.G800D	SIDM02021	Esophageal Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation altering degron motif	0.7198
p.D820N	SIDM00935	Other Solid Cancers	GDSC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2222
p.D820N	CAL-39	vulva	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2222
p.Y788C	SIDM00537	Colorectal Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.1111
p.Y788C	ACH-000982	Colon/Colorectal Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.1111
p.Y788C	ACH-001345	Colon/Colorectal Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.1111
p.Y788C	GP5d	large intestine	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.1111
p.S799G	SIDM00980	Gastric Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation altering degron motif	0.6993
p.S799G	ACH-000948	Gastric Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation altering degron motif	0.6993
p.S799G	23132-87	stomach	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation altering degron motif	0.6993
p.H834Y	SIDM01454	Kidney Carcinoma	GDSC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2222
p.H834Y	ACH-000459	Kidney Cancer	CCLE	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.2222
p.L604H	ACH-000831	Endometrial/Uterine Cancer	CCLE	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation altering degron motif	0.7313
p.E175D	ACH-001719	Ovarian Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1944
p.G787E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	796:801	Mutation rewiring degron network	0.0833
p.T157A	EN	endometrium	COSMIC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.L173F	MCC13	skin	COSMIC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.25
p.A833T	MN-60	haematopoietic and lymphoid tissue	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.25
p.Q160R	LS-411N	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.G826E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation altering degron motif	0.7199
p.P609Q	AN3-CA	endometrium	COSMIC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation altering degron motif	0.7035
p.I823V	NCI-H82	lung	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	824:830	Mutation rewiring degron network	0.3056
p.L603V	MEL-HO	skin	COSMIC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.3056
p.P598L	IPC-298	skin	COSMIC	LTPPTT	DEG_SCF_FBW7_1	604:609	Mutation rewiring degron network	0.1667
p.R166Q	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7329

Kaplan plot for PPARGC1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPARGC1B

UniProt ID: Q86YN6

Entrez ID: 133522

Protein name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPARGC1B in