DegronMD

Uniprot ID: Q86YN6

Source protein: Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Source gene: PPARGC1B

Class: DEG_SCF_TRCP1_1

Location: 824:830

E3 ligase: BTRC

DEGRON score: 0.9242

ASA_SCORE: 80.0429

COIL: 0.924

CONS_SCORE: 0.4481

DSS_SCORE: 0.8222

HELIX: 0.0659

FCONS_SCORE: 0.9277

RIG_SCORE: 0.5649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S832C	TCGA-05-4250	LUAD	TCGA	DSGVSPT	DEG_SCF_TRCP1_1	0.2778
p.S832C	DO24457	LUAD	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	0.2778
p.D819Y	TCGA-A8-A0A7	BRCA	TCGA	DSGVSPT	DEG_SCF_TRCP1_1	0.1944
p.D833N	TCGA-DD-AACU	LIHC	TCGA	DSGVSPT	DEG_SCF_TRCP1_1	0.25
p.A826T	DO233731	GACA	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	0.7139
p.R830W	DO14067	GBM	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	0.8634
p.R830W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	0.8634
p.R830W	NCI-SNU-1	stomach	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	0.8634
p.S817L	DO220851	MELA	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	0.1389
p.T820M	DO42713	UCEC	ICGC	DSGVSPT	DEG_SCF_TRCP1_1	0.2222
p.D820N	SIDM00935	Other Solid Cancers	GDSC	DSGVSPT	DEG_SCF_TRCP1_1	0.2222
p.D820N	CAL-39	vulva	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	0.2222
p.H834Y	SIDM01454	Kidney Carcinoma	GDSC	DSGVSPT	DEG_SCF_TRCP1_1	0.2222
p.H834Y	ACH-000459	Kidney Cancer	CCLE	DSGVSPT	DEG_SCF_TRCP1_1	0.2222
p.A833T	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	0.25
p.G826E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	0.7199
p.I823V	NCI-H82	lung	COSMIC	DSGVSPT	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SCF_TRCP1_1	824:830	DSGVSPT	BTRC	0.9242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons