DegronMD

Uniprot ID: Q86YN6

Source protein: Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Source gene: PPARGC1B

Class: DEG_SCF_FBW7_1

Location: 604:609

E3 ligase: FBXW7

DEGRON score: 0.9666

ASA_SCORE: 93.4333

COIL: 0.9668

CONS_SCORE: 0.4257

DSS_SCORE: 0.6195

HELIX: 0.0068

FCONS_SCORE: 0.8351

RIG_SCORE: 0.6539

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G600D	TCGA-B5-A3FA	UCEC	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.2222
p.G600D	DO52402	UCEC	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.2222
p.P607L	TCGA-GU-A42Q	BLCA	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.6471
p.P607L	DO485	BLCA	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.6471
p.R597Q	DO222804	COCA	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.1389
p.R597Q	DO36531	READ	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.1389
p.R597Q	IGROV-1	ovary	COSMIC	LTPPTT	DEG_SCF_FBW7_1	0.1389
p.A607T	DO228542	GACA	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.7139
p.A607T	DO48032	STAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.7139
p.R619H	DO10880	GBM	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.0556
p.R619H	DO26015	LUAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.0556
p.R619H	DO46657	PAAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.0556
p.H594R	DO228019	SKCA	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.0556
p.H603Y	DO37567	SKCM	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.3056
p.L604H	ACH-000831	Endometrial/Uterine Cancer	CCLE	LTPPTT	DEG_SCF_FBW7_1	0.7313
p.P609Q	AN3-CA	endometrium	COSMIC	LTPPTT	DEG_SCF_FBW7_1	0.7035
p.L603V	MEL-HO	skin	COSMIC	LTPPTT	DEG_SCF_FBW7_1	0.3056
p.P598L	IPC-298	skin	COSMIC	LTPPTT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SCF_FBW7_1	604:609	LTPPTT	FBXW7	0.9666	More...
Q9UBK2	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	DEG_SCF_FBW7_1	294:299	LTPPTT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons