DegronMD

Uniprot ID: Q9UBK2

Source protein: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Source gene: PPARGC1A

Class: DEG_SCF_FBW7_1

Location: 294:299

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 87.4833

COIL: 0.9683

CONS_SCORE: 0.7013

DSS_SCORE: 0.7444

HELIX: 0.0087

FCONS_SCORE: 1.1445

RIG_SCORE: 0.5962

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K303E	TCGA-16-1460	GBM	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.3333
p.K303E	DO13360	GBM	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.3333
p.N305I	TCGA-55-7994	LUAD	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.1667
p.N305I	DO45311	LUAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.1667
p.A304D	TCGA-E6-A1LX	UCEC	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.1944
p.A304D	DO229031	LICA	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.1944
p.A304D	DO41020	UCEC	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.1944
p.K303R	TCGA-EE-A2A2	SKCM	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.3333
p.K303R	DO37583	SKCM	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.3333
p.P300S	TCGA-FR-A8YC	SKCM	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.3056
p.P300S	DO50301	SKCM	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.3056
p.G293V	TCGA-L9-A7SV	LUAD	TCGA	LTPPTT	DEG_SCF_FBW7_1	0.3056
p.G293V	DO49875	LUAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.3056
p.H302N	DO23444	LINC	ICGC	LTPPTT	DEG_SCF_FBW7_1	0.25
p.A304V	H2804	pleura	COSMIC	LTPPTT	DEG_SCF_FBW7_1	0.1944
p.D303Y	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPTT	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SCF_FBW7_1	604:609	LTPPTT	FBXW7	0.9666	More...
Q9UBK2	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	DEG_SCF_FBW7_1	294:299	LTPPTT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons