DegronMD - Q9UBK2(PPARGC1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K303E	TCGA-16-1460	GBM	TCGA	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation substituting flanking lysine	0.3333
p.K303E	DO13360	GBM	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation substituting flanking lysine	0.3333
p.N305I	TCGA-55-7994	LUAD	TCGA	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.1667
p.N305I	DO45311	LUAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.1667
p.R375W	TCGA-A6-3809	COAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.25
p.R375W	TCGA-AA-3715	COAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.25
p.R375W	DO8018	COAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.25
p.R375W	DO8722	COAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.25
p.R371S	TCGA-A6-6782	COAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1389
p.R371S	DO10534	COAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1389
p.R371M	TCGA-B5-A3FA	UCEC	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1389
p.R371M	DO52402	UCEC	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1389
p.G382A	TCGA-BS-A0UM	UCEC	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6429
p.G382A	DO43065	UCEC	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6429
p.A304D	TCGA-E6-A1LX	UCEC	TCGA	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.1944
p.A304D	DO229031	LICA	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.1944
p.A304D	DO41020	UCEC	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.1944
p.K303R	TCGA-EE-A2A2	SKCM	TCGA	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation substituting flanking lysine	0.3333
p.K303R	DO37583	SKCM	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation substituting flanking lysine	0.3333
p.S392F	TCGA-ER-A42L	SKCM	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.S392F	DO223910	SKCM	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.P300S	TCGA-FR-A8YC	SKCM	TCGA	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.3056
p.P300S	DO50301	SKCM	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.3056
p.G293V	TCGA-L9-A7SV	LUAD	TCGA	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.3056
p.G293V	DO49875	LUAD	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.3056
p.R375Q	TCGA-M7-A721	PRAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.25
p.R375Q	DO48614	PRAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.25
p.H302N	DO23444	LINC	ICGC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.25
p.E370K	DO229446	SKCA	ICGC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1111
p.H368Y	SIDM00151	Ovarian Carcinoma	GDSC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0556
p.H368Y	ACH-000966	Ovarian Cancer	CCLE	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0556
p.H368Y	IGROV-1	ovary	COSMIC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0556
p.G382R	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6457
p.G382R	ACH-000826	Lung Cancer	CCLE	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6457
p.G382R	CAL-12T	lung	COSMIC	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6457
p.H384Y	ACH-001982	Metastasis	CCLE	LRLFGD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.3056
p.A304V	H2804	pleura	COSMIC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation rewiring degron network	0.1944
p.D303Y	RC-K8	haematopoietic and lymphoid tissue	COSMIC	LTPPTT	DEG_SCF_FBW7_1	294:299	Mutation substituting flanking lysine	0.3333

Kaplan plot for PPARGC1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPARGC1A

UniProt ID: Q9UBK2

Entrez ID: 10891

Protein name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPARGC1A in