DegronMD

Uniprot ID: Q9UBK2

Source protein: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Source gene: PPARGC1A

Class: LIG_APCC_ABBA_1

Location: 378:383

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6648

ASA_SCORE: 72

COIL: 0.5928

CONS_SCORE: 0.6607

DSS_SCORE: 0.4152

HELIX: 0.1763

FCONS_SCORE: 1.1599

RIG_SCORE: 0.737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R375W	TCGA-A6-3809	COAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.25
p.R375W	TCGA-AA-3715	COAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.25
p.R375W	DO8018	COAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.25
p.R375W	DO8722	COAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.25
p.R371S	TCGA-A6-6782	COAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.1389
p.R371S	DO10534	COAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.1389
p.R371M	TCGA-B5-A3FA	UCEC	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.1389
p.R371M	DO52402	UCEC	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.1389
p.G382A	TCGA-BS-A0UM	UCEC	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.6429
p.G382A	DO43065	UCEC	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.6429
p.S392F	TCGA-ER-A42L	SKCM	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.0833
p.S392F	DO223910	SKCM	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.0833
p.R375Q	TCGA-M7-A721	PRAD	TCGA	LRLFGD	LIG_APCC_ABBA_1	0.25
p.R375Q	DO48614	PRAD	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.25
p.E370K	DO229446	SKCA	ICGC	LRLFGD	LIG_APCC_ABBA_1	0.1111
p.H368Y	SIDM00151	Ovarian Carcinoma	GDSC	LRLFGD	LIG_APCC_ABBA_1	0.0556
p.H368Y	ACH-000966	Ovarian Cancer	CCLE	LRLFGD	LIG_APCC_ABBA_1	0.0556
p.H368Y	IGROV-1	ovary	COSMIC	LRLFGD	LIG_APCC_ABBA_1	0.0556
p.G382R	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	LRLFGD	LIG_APCC_ABBA_1	0.6457
p.G382R	ACH-000826	Lung Cancer	CCLE	LRLFGD	LIG_APCC_ABBA_1	0.6457
p.G382R	CAL-12T	lung	COSMIC	LRLFGD	LIG_APCC_ABBA_1	0.6457
p.H384Y	ACH-001982	Metastasis	CCLE	LRLFGD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBK2	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	LIG_APCC_ABBA_1	378:383	LRLFGD	APC,CDC20,FZR1	0.6648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons