DegronMD

Uniprot ID: Q86YN6

Source protein: Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Source gene: PPARGC1B

Class: DEG_Kelch_Keap1_1

Location: 796:801

E3 ligase: KEAP1

DEGRON score: 0.957

ASA_SCORE: 85.25

COIL: 0.9337

CONS_SCORE: 0.5068

DSS_SCORE: 0.7914

HELIX: 0.0523

FCONS_SCORE: 1.044

RIG_SCORE: 0.4966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L805F	TCGA-BF-AAP6	SKCM	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.L805F	DO219470	SKCM	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2222
p.E787K	TCGA-CF-A47X	BLCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.G800D	SIDM02021	Esophageal Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.7198
p.Y788C	SIDM00537	Colorectal Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.1111
p.Y788C	ACH-000982	Colon/Colorectal Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.1111
p.Y788C	ACH-001345	Colon/Colorectal Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.1111
p.Y788C	GP5d	large_intestine	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.1111
p.S799G	SIDM00980	Gastric Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.6993
p.S799G	ACH-000948	Gastric Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.6993
p.S799G	23132-87	stomach	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.6993
p.G787E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons