DegronMD - Q86Z02(HIPK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I555M	TCGA-05-5428	LUAD	TCGA	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.0556
p.A595V	TCGA-14-0865	GBM	TCGA	ASSST	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.V178I	TCGA-AP-A051	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.1667
p.V178I	DO42673	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.1667
p.T572I	TCGA-AX-A05Z	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.25
p.D90H	TCGA-CQ-7063	HNSC	TCGA	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.D90H	DO14702	HNSC	ICGC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.Q104K	TCGA-D3-A2JP	SKCM	TCGA	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.Q104K	DO47407	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.P565T	TCGA-EE-A20F	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	565:569	Mutation altering degron motif	0.7031
p.P558L	TCGA-EE-A2MJ	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1389
p.T164I	TCGA-FD-A3SL	BLCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.25
p.T164I	TCGA-FD-A3SL	BLCA	TCGA	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2222
p.T164I	DO732	BLCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.25
p.T164I	DO732	BLCA	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2222
p.T151N	TCGA-IB-7651	PAAD	TCGA	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1944
p.T151N	DO46657	PAAD	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1944
p.P558S	TCGA-IM-A3U3	THCA	TCGA	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1389
p.F100Y	TCGA-SX-A71V	KIRP	TCGA	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.3056
p.F100Y	DO49780	KIRP	ICGC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.3056
p.H562D	TCGA-UC-A7PG	CESC	TCGA	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.25
p.D567Y	DO219012	BLCA	ICGC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation altering degron motif	0.7325
p.R170W	DO10092	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation altering degron motif	0.8634
p.R170W	DO232761	PBCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation altering degron motif	0.8634
p.R170W	DOK	upper aerodigestive tract	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation altering degron motif	0.8634
p.E166G	DO8264	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.3056
p.E166G	DO8264	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.T159A	DO10839	ESAD	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7139
p.Q163E	DO233190	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.2222
p.Q163E	DO233190	GACA	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.R171K	DO14998	HNSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation altering degron motif	0.7237
p.P569A	DO44439	HNSC	ICGC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation altering degron motif	0.7503
p.R600I	DO22237	LGG	ICGC	ASSST	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1667
p.C89F	DO229028	LICA	ICGC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.A89T	DO45107	LIRI	ICGC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.I181M	DO24005	LUAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.0833
p.R556M	DO45461	LUSC	ICGC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation substituting flanking lysine	0.1944
p.S557F	DO222880	MELA	ICGC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1111
p.L587F	DO51474	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.25
p.L575F	DO219992	SARC	ICGC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1667
p.S169F	DO229462	SKCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation altering degron motif	0.7982
p.S593F	DO50288	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.7982
p.P153S	DO51275	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.D91G	DO229213	THCA	ICGC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2222
p.V594I	DO42312	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.7076
p.T147P	DO41903	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0833
p.E166D	DO42568	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation rewiring degron network	0.3056
p.E166D	DO42568	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.S98A	SIDM00845	Burkitt's Lymphoma	GDSC	AATST	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.7588
p.N149S	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.N149S	ACH-000603	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.N149S	BEN	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.S587N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.25
p.S587N	ACH-000980	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.25
p.S587N	NCI-H1155	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.25
p.S170T	ACH-000600	Kidney Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	167:172	Mutation altering degron motif	0.6005
p.R150W	DOK	upper aerodigestive tract	COSMIC	AATTT	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.G104E	JHH-7	liver	COSMIC	AATST	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.I560V	CW-2	large intestine	COSMIC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1944
p.D572G	NCI-H2066	lung	COSMIC	PNTST	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.25

Kaplan plot for HIPK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIPK1

UniProt ID: Q86Z02

Entrez ID: 204851

Protein name: Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HIPK1 in