DegronMD

Uniprot ID: Q86Z02

Source protein: Homeodomain-interacting protein kinase 1

Source gene: HIPK1

Class: DEG_SPOP_SBC_1

Location: 565:569

E3 ligase: SPOP

DEGRON score: 0.5677

ASA_SCORE: 76.06

COIL: 0.8896

CONS_SCORE: 0.4211

DSS_SCORE: 0.3574

HELIX: 0.061

FCONS_SCORE: 1.0541

RIG_SCORE: 0.7267

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I555M	TCGA-05-5428	LUAD	TCGA	PNTST	DEG_SPOP_SBC_1	0.0556
p.T572I	TCGA-AX-A05Z	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	0.25
p.P565T	TCGA-EE-A20F	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	0.7031
p.P558L	TCGA-EE-A2MJ	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	0.1389
p.P558S	TCGA-IM-A3U3	THCA	TCGA	PNTST	DEG_SPOP_SBC_1	0.1389
p.H562D	TCGA-UC-A7PG	CESC	TCGA	PNTST	DEG_SPOP_SBC_1	0.25
p.D567Y	DO219012	BLCA	ICGC	PNTST	DEG_SPOP_SBC_1	0.7325
p.P569A	DO44439	HNSC	ICGC	PNTST	DEG_SPOP_SBC_1	0.7503
p.R556M	DO45461	LUSC	ICGC	PNTST	DEG_SPOP_SBC_1	0.1944
p.S557F	DO222880	MELA	ICGC	PNTST	DEG_SPOP_SBC_1	0.1111
p.L575F	DO219992	SARC	ICGC	PNTST	DEG_SPOP_SBC_1	0.1667
p.I560V	CW-2	large_intestine	COSMIC	PNTST	DEG_SPOP_SBC_1	0.1944
p.D572G	NCI-H2066	lung	COSMIC	PNTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	565:569	PNTST	SPOP	0.5677	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12823:12827	PNTST	SPOP	0.6675	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	1904:1908	PNTST	SPOP	0.8978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons