DegronMD - Q9P2D1(CHD7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N324S	TCGA-19-5956	GBM	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.0556
p.N324S	DO13863	GBM	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.0556
p.G146V	TCGA-55-5899	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.G146V	DO26042	LUAD	ICGC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.V152L	TCGA-63-A5MJ	LUSC	TCGA	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.V152L	DO219149	LUSC	ICGC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R312Q	TCGA-86-8279	LUAD	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.6218
p.R312Q	TCGA-AP-A056	UCEC	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.6218
p.R312Q	DO24140	LUAD	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.6218
p.R312Q	DO43971	UCEC	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.6218
p.L1909M	TCGA-AJ-A2QO	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.3056
p.L1909M	TCGA-CN-6988	HNSC	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.3056
p.L1909M	DO14208	HNSC	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.3056
p.L1909M	DO42177	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.3056
p.F2458C	TCGA-AP-A056	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.25
p.F2458C	DO43971	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.25
p.L2461F	TCGA-AP-A056	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1667
p.L2461F	DO43971	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1667
p.S2462P	TCGA-AP-A059	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1389
p.S2462P	DO41361	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1389
p.R1914H	TCGA-AP-A0LM	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.1667
p.R1914H	TCGA-BR-6452	STAD	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.1667
p.R1914H	DO38404	STAD	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.1667
p.R1914H	DO43306	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.1667
p.S294Y	TCGA-AP-A1DV	UCEC	TCGA	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.6009
p.S294Y	DO43186	UCEC	ICGC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.6009
p.S311F	TCGA-AR-A24Q	BRCA	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.7982
p.S311F	DO3524	BRCA	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.7982
p.S143Y	TCGA-AX-A1CE	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.712
p.S143Y	DO42280	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.712
p.R1912C	TCGA-AX-A1CE	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.2222
p.R1912C	DO42280	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.2222
p.H134Y	TCGA-B5-A11E	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.H134Y	DO41644	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.N2457Y	TCGA-BL-A13I	BLCA	TCGA	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.2778
p.N2457Y	DO452	BLCA	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.2778
p.N317K	TCGA-C4-A0EZ	BLCA	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.25
p.N317K	DO476	BLCA	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.25
p.F2458V	TCGA-CA-6717	COAD	TCGA	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.25
p.F2458V	DO8264	COAD	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.25
p.N724K	TCGA-CR-7380	HNSC	TCGA	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.25
p.N724K	DO14734	HNSC	ICGC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.25
p.N2457I	TCGA-D1-A103	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.2778
p.N2457I	DO42312	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.2778
p.R1914C	TCGA-D1-A16F	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.1667
p.R1914C	DO42408	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation rewiring degron network	0.1667
p.A284T	TCGA-D1-A1NZ	UCEC	TCGA	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.0833
p.A284T	DO41536	UCEC	ICGC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.0833
p.S1907L	TCGA-EB-A4XL	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation altering degron motif	0.7667
p.S1907L	DO47401	SKCM	ICGC	PNTST	DEG_SPOP_SBC_1	1904:1908	Mutation altering degron motif	0.7667
p.P314A	TCGA-FD-A43P	BLCA	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.7503
p.P314A	DO44049	BLCA	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation altering degron motif	0.7503
p.Q320E	TCGA-FD-A43P	BLCA	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.1667
p.Q320E	TCGA-R6-A6Y0	ESCA	TCGA	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.1667
p.Q320E	DO44049	BLCA	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.1667
p.P287L	TCGA-HU-A4GN	STAD	TCGA	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.1667
p.P287L	DO233281	GACA	ICGC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.1667
p.P287L	DO47833	STAD	ICGC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.1667
p.E741K	TCGA-LP-A5U2	CESC	TCGA	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.1389
p.E741K	DO51610	CESC	ICGC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.1389
p.A149S	TCGA-OR-A5KB	ACC	TCGA	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.P153Q	TCGA-W5-AA34	CHOL	TCGA	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.E2450Q	DO223059	ESCA	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.3056
p.V152A	DO233913	GACA	ICGC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.D2443Y	DO229025	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1111
p.D2443Y	DO232051	ORCA	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1111
p.S2453I	DO229027	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation altering degron motif	0.7341
p.M144I	DO229037	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.3056
p.S316I	DO50921	LICA	ICGC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.2778
p.L290F	DO222743	MELA	ICGC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.25
p.T289I	DO222875	MELA	ICGC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2222
p.P733S	DO229502	SKCA	ICGC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.5641
p.R286G	SIDM01265	Plasma Cell Myeloma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.1389
p.R286G	SIDM00930	Osteosarcoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.1389
p.R286G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.1389
p.T730I	SIDM00232	Kidney Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.8189
p.T730I	ACH-002168	Kidney Cancer	CCLE	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.8189
p.T730I	NCC021	kidney	COSMIC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.8189
p.S296N	SIDM00845	Burkitt's Lymphoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.818
p.S296N	SIDM01519	Head and Neck Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.818
p.S296N	Daudi	haematopoietic and lymphoid tissue	COSMIC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.818
p.I304V	SIDM00845	Burkitt's Lymphoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2778
p.I304V	SIDM00845	Burkitt's Lymphoma	GDSC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.3056
p.I304V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2778
p.I304V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.3056
p.I304V	SIDM01519	Head and Neck Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2778
p.I304V	SIDM01519	Head and Neck Carcinoma	GDSC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.3056
p.I304V	ACH-000786	Lymphoma	CCLE	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2778
p.I304V	ACH-000786	Lymphoma	CCLE	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.3056
p.I304V	ACH-000992	Head and Neck Cancer	CCLE	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2778
p.I304V	ACH-000992	Head and Neck Cancer	CCLE	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.3056
p.I304V	Daudi	haematopoietic and lymphoid tissue	COSMIC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation rewiring degron network	0.2778
p.I304V	Daudi	haematopoietic and lymphoid tissue	COSMIC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.3056
p.S2462T	SIDM00845	Burkitt's Lymphoma	GDSC	ATSST	DEG_SPOP_SBC_1	2451:2455	Mutation rewiring degron network	0.1389
p.G744S	SIDM00393	Gastric Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.0556
p.G744S	SIDM00032	Bladder Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.0556
p.G744S	SIDM01173	Rhabdomyosarcoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation rewiring degron network	0.0556
p.R133K	SIDM01118	Small Cell Lung Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R133K	ACH-002175	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R133K	NCI-H740	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.D728H	SIDM00183	Small Cell Lung Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.6577
p.D728H	SIDM01648	Non-Cancerous	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.6577
p.D728H	ACH-002356	Non-Cancerous	CCLE	LDKTPPPS	DEG_SCF_FBW7_1	727:734	Mutation altering degron motif	0.6577
p.R295Q	SIDM00839	Colorectal Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.6218
p.R295Q	LoVo	large intestine	COSMIC	SSRSQTVPSP	DEG_COP1_1	293:302	Mutation altering degron motif	0.6218
p.N319K	SIDM01611	Endometrial Carcinoma	GDSC	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.1944
p.N319K	ACH-000996	Endometrial/Uterine Cancer	CCLE	NNSGQYSRYP	CBL_PTK	305:314	Mutation rewiring degron network	0.1944
p.G146D	ACH-000930	Breast Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD7

UniProt ID: Q9P2D1

Entrez ID: 55636

Protein name: Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD7 in