DegronMD

Uniprot ID: Q9P2D1

Source protein: Chromodomain-helicase-DNA-binding protein 7

Source gene: CHD7

Class: CBL_PTK

Location: 305:314

E3 ligase: CBL

DEGRON score: 0.7339

ASA_SCORE: 88.14

COIL: 0.9144

CONS_SCORE: 0.3175

DSS_SCORE: 0.5436

HELIX: 0.0412

FCONS_SCORE: 1.0437

RIG_SCORE: 0.6922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N324S	TCGA-19-5956	GBM	TCGA	NNSGQYSRYP	CBL_PTK	0.0556
p.N324S	DO13863	GBM	ICGC	NNSGQYSRYP	CBL_PTK	0.0556
p.R312Q	TCGA-86-8279	LUAD	TCGA	NNSGQYSRYP	CBL_PTK	0.6218
p.R312Q	TCGA-AP-A056	UCEC	TCGA	NNSGQYSRYP	CBL_PTK	0.6218
p.R312Q	DO24140	LUAD	ICGC	NNSGQYSRYP	CBL_PTK	0.6218
p.R312Q	DO43971	UCEC	ICGC	NNSGQYSRYP	CBL_PTK	0.6218
p.S311F	TCGA-AR-A24Q	BRCA	TCGA	NNSGQYSRYP	CBL_PTK	0.7982
p.S311F	DO3524	BRCA	ICGC	NNSGQYSRYP	CBL_PTK	0.7982
p.N317K	TCGA-C4-A0EZ	BLCA	TCGA	NNSGQYSRYP	CBL_PTK	0.25
p.N317K	DO476	BLCA	ICGC	NNSGQYSRYP	CBL_PTK	0.25
p.P314A	TCGA-FD-A43P	BLCA	TCGA	NNSGQYSRYP	CBL_PTK	0.7503
p.P314A	DO44049	BLCA	ICGC	NNSGQYSRYP	CBL_PTK	0.7503
p.Q320E	TCGA-FD-A43P	BLCA	TCGA	NNSGQYSRYP	CBL_PTK	0.1667
p.Q320E	TCGA-R6-A6Y0	ESCA	TCGA	NNSGQYSRYP	CBL_PTK	0.1667
p.Q320E	DO44049	BLCA	ICGC	NNSGQYSRYP	CBL_PTK	0.1667
p.S316I	DO50921	LICA	ICGC	NNSGQYSRYP	CBL_PTK	0.2778
p.I304V	SIDM00845	Burkitt's Lymphoma	GDSC	NNSGQYSRYP	CBL_PTK	0.3056
p.I304V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	NNSGQYSRYP	CBL_PTK	0.3056
p.I304V	SIDM01519	Head and Neck Carcinoma	GDSC	NNSGQYSRYP	CBL_PTK	0.3056
p.I304V	ACH-000786	Lymphoma	CCLE	NNSGQYSRYP	CBL_PTK	0.3056
p.I304V	ACH-000992	Head and Neck Cancer	CCLE	NNSGQYSRYP	CBL_PTK	0.3056
p.I304V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NNSGQYSRYP	CBL_PTK	0.3056
p.N319K	SIDM01611	Endometrial Carcinoma	GDSC	NNSGQYSRYP	CBL_PTK	0.1944
p.N319K	ACH-000996	Endometrial/Uterine Cancer	CCLE	NNSGQYSRYP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	CBL_PTK	305:314	NNSGQYSRYP	CBL	0.7339	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons