DegronMD

Uniprot ID: Q9P2D1

Source protein: Chromodomain-helicase-DNA-binding protein 7

Source gene: CHD7

Class: DEG_SPOP_SBC_1

Location: 2451:2455

E3 ligase: SPOP

DEGRON score: 0.9815

ASA_SCORE: 82.74

COIL: 0.8732

CONS_SCORE: 0.3321

DSS_SCORE: 0.383

HELIX: 0.108

FCONS_SCORE: 1.0734

RIG_SCORE: 0.6581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F2458C	TCGA-AP-A056	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.25
p.F2458C	DO43971	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.25
p.L2461F	TCGA-AP-A056	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.1667
p.L2461F	DO43971	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.1667
p.S2462P	TCGA-AP-A059	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.1389
p.S2462P	DO41361	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.1389
p.N2457Y	TCGA-BL-A13I	BLCA	TCGA	ATSST	DEG_SPOP_SBC_1	0.2778
p.N2457Y	DO452	BLCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.2778
p.F2458V	TCGA-CA-6717	COAD	TCGA	ATSST	DEG_SPOP_SBC_1	0.25
p.F2458V	DO8264	COAD	ICGC	ATSST	DEG_SPOP_SBC_1	0.25
p.N2457I	TCGA-D1-A103	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.2778
p.N2457I	DO42312	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.2778
p.E2450Q	DO223059	ESCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.3056
p.D2443Y	DO229025	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	0.1111
p.D2443Y	DO232051	ORCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.1111
p.S2453I	DO229027	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	0.7341
p.S2462T	SIDM00845	Burkitt's Lymphoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with CHD7 mutations

All proteins holding degron of ATSST