DegronMD

Uniprot ID: Q15858

Source protein: Sodium channel protein type 9 subunit alpha

Source gene: SCN9A

Class: DEG_SPOP_SBC_1

Location: 1948:1952

E3 ligase: SPOP

DEGRON score: 0.9534

ASA_SCORE: 81.98

COIL: 0.9608

CONS_SCORE: 0.2696

DSS_SCORE: 0.7299

HELIX: 0.0202

FCONS_SCORE: 0.955

RIG_SCORE: 0.5538

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1961H	TCGA-85-A4QQ	LUSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0833
p.Y1947H	TCGA-CV-7434	HNSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.3056
p.S1943Y	TCGA-D3-A1Q3	SKCM	TCGA	ATSST	DEG_SPOP_SBC_1	0.1944
p.R1962K	TCGA-EB-A41A	SKCM	TCGA	ATSST	DEG_SPOP_SBC_1	0.0556
p.N1940S	DO8842	COAD	ICGC	ATSST	DEG_SPOP_SBC_1	0.1111
p.D1947N	DO222579	ESCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.3056
p.S1951F	DO222810	MELA	ICGC	ATSST	DEG_SPOP_SBC_1	0.7982
p.S1951F	CP66-MEL	skin	COSMIC	ATSST	DEG_SPOP_SBC_1	0.7982
p.S1950L	DO50724	ORCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.8778
p.T1946R	DO223272	SARC	ICGC	ATSST	DEG_SPOP_SBC_1	0.2778
p.T1946R	KNS-81-FD	central_nervous_system	COSMIC	ATSST	DEG_SPOP_SBC_1	0.2778
p.T1946R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	0.2778
p.S1954Y	DO47509	SKCM	ICGC	ATSST	DEG_SPOP_SBC_1	0.2778
p.E1939D	DO41644	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0833
p.T1946A	DO43891	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.2778
p.S1940F	SIDM00190	Melanoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1111
p.S1940F	ACH-002097	Skin Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.1111
p.S1940F	CP66-MEL	skin	COSMIC	ATSST	DEG_SPOP_SBC_1	0.1111
p.P1953T	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.P1953T	ACH-000638	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.3056
p.P1953T	NCI-H441	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.3056
p.P1944S	ACH-001410	Bladder Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.2222
p.P1953L	ACH-002044	Head and Neck Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with SCN9A mutations

All proteins holding degron of ATSST