DegronMD

Uniprot ID: Q14980

Source protein: Nuclear mitotic apparatus protein 1

Source gene: NUMA1

Class: DEG_SPOP_SBC_1

Location: 1850:1854

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 77.44

COIL: 0.7662

CONS_SCORE: 0.6745

DSS_SCORE: 0.5015

HELIX: 0.1882

FCONS_SCORE: 0.9978

RIG_SCORE: 0.6707

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1852Y	TCGA-B5-A1MX	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.8231
p.T1851A	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.6028
p.T1851A	ACH-000840	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.6028
p.T1851A	HCC-366	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.6028
p.S1852T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.7116
p.S1852T	ACH-000840	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.7116
p.S1852T	HCC-366	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.7116
p.A1841T	SIDM00799	Glioblastoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.0833
p.A1841T	ACH-000558	Brain Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.0833
p.A1841T	A172	central_nervous_system	COSMIC	ATSST	DEG_SPOP_SBC_1	0.0833
p.A1843T	SIDM01617	Endometrial Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1389
p.A1843T	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.1389
p.D1864N	SIDM01588	Endometrial Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.0556
p.D1864N	ACH-000993	Endometrial/Uterine Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.0556
p.Q1845H	ACH-000954	Endometrial/Uterine Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.1944
p.R1863H	SNU-1040	large_intestine	COSMIC	ATSST	DEG_SPOP_SBC_1	0.0833
p.R1861H	SNU-1040	large_intestine	COSMIC	ATSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with NUMA1 mutations

All proteins holding degron of ATSST