DegronMD - Q8IXK0(PHC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L750F	TCGA-09-2049	OV	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1944
p.Q260P	TCGA-14-0866	GBM	TCGA	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.3056
p.Q260P	TCGA-14-0866	GBM	TCGA	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.3056
p.Q260P	DO11878	GBM	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.3056
p.Q260P	DO11878	GBM	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.3056
p.P263S	TCGA-90-A4ED	LUSC	TCGA	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.5641
p.P245H	TCGA-AG-A002	READ	TCGA	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.1389
p.S11Y	TCGA-AG-A002	READ	TCGA	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.712
p.T759I	TCGA-AG-A014	READ	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation altering degron motif	0.7078
p.T255M	TCGA-EO-A22U	UCEC	TCGA	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.7423
p.S37G	TCGA-F7-A624	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.S37G	DO44440	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.P752H	TCGA-IB-7651	PAAD	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.25
p.S21N	TCGA-JY-A6FH	ESCA	TCGA	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.0833
p.S21N	TCGA-JY-A6FH	ESCA	TCGA	ATSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.3056
p.S21N	TCGA-JY-A6FH	ESCA	TCGA	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2778
p.P261L	TCGA-MT-A67D	HNSC	TCGA	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.6471
p.G765D	TCGA-XF-A8HF	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1667
p.E2D	DO48389	BLCA	ICGC	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1667
p.G252C	DO48414	BLCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.76
p.E262Q	DO51893	BLCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.6744
p.G257V	DO228431	BRCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.6421
p.E249K	DO3662	BRCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.25
p.E249A	DO3662	BRCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.25
p.V277L	DO4287	BRCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0833
p.G277D	DO8018	COAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0833
p.R262C	DO8119	COAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.8301
p.R262C	DO228138	PBCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.8301
p.R262C	DO42280	UCEC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.8301
p.V277M	DO234389	ESAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0833
p.A270V	DO233115	GACA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.2778
p.G24S	DO233888	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6993
p.P5L	DO233823	GACA	ICGC	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.25
p.P5L	DO41758	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.25
p.P11Q	DO20102	KIRC	ICGC	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7035
p.C271Y	DO17188	KIRC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.25
p.P272T	DO228978	LICA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.2222
p.L250I	DO229019	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.2778
p.L250I	DO50861	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.2778
p.H20N	DO229026	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7423
p.H20N	DO229031	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7423
p.Q244K	DO229045	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.1111
p.D255N	DO229058	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.6932
p.R262H	DO50849	LICA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.8244
p.R262H	DO231645	LINC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.8244
p.R262H	22RV1	prostate	COSMIC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.8244
p.D263G	DO44832	LICA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.7198
p.P254S	DO230550	LUSC	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.5641
p.V277A	DO45494	LUSC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0833
p.V277A	SNU-1040	large intestine	COSMIC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0833
p.P37H	DO37511	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.P243S	DO37406	SKCM	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.0833
p.P243L	DO50291	SKCM	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.0833
p.P272S	DO51776	STAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.2222
p.A251S	DO229253	THCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.3056
p.A251S	DO229253	THCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0556
p.D255E	DO41235	UCEC	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.6758
p.C28Y	DO41193	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1111
p.C28Y	DO41193	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.P261S	DO42472	UCEC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation altering degron motif	0.6752
p.V7D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.V7D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ATSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.0833
p.V7D	ACH-002256	Leukemia	CCLE	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.V7D	ACH-002256	Leukemia	CCLE	ATSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.0833
p.V7D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.V7D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.0833
p.P254A	SIDM00177	Melanoma	GDSC	LKPTPGGS	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.6392
p.A16V	SIDM00534	Colorectal Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.5825
p.A16V	ACH-000986	Colon/Colorectal Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.5825
p.G278C	ACH-002026	Endometrial/Uterine Cancer	CCLE	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation rewiring degron network	0.0556
p.G36W	WM35	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0833
p.Y275H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PLPTPAQS	DEG_SCF_FBW7_1	261:268	Mutation blocking phosphorylation signal	0.5833
p.Q26H	HCT-15	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7582
p.Q32H	SCaBER	urinary tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHC2

UniProt ID: Q8IXK0

Entrez ID: 1912

Protein name: Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHC2 in