DegronMD

Uniprot ID: Q8IXK0

Source protein: Polyhomeotic-like protein 2

Source gene: PHC2

Class: DEG_SCF_FBW7_1

Location: 252:259

E3 ligase: FBXW7

DEGRON score: 0.9936

ASA_SCORE: 85.2625

COIL: 0.9639

CONS_SCORE: 0.4798

DSS_SCORE: 0.7293

HELIX: 0.0131

FCONS_SCORE: 1.1263

RIG_SCORE: 0.5569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q260P	TCGA-14-0866	GBM	TCGA	LKPTPGGS	DEG_SCF_FBW7_1	0.3056
p.Q260P	DO11878	GBM	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.3056
p.P245H	TCGA-AG-A002	READ	TCGA	LKPTPGGS	DEG_SCF_FBW7_1	0.1389
p.T255M	TCGA-EO-A22U	UCEC	TCGA	LKPTPGGS	DEG_SCF_FBW7_1	0.7423
p.G252C	DO48414	BLCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.76
p.G257V	DO228431	BRCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.6421
p.E249K	DO3662	BRCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.25
p.E249A	DO3662	BRCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.25
p.L250I	DO229019	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.2778
p.L250I	DO50861	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.2778
p.Q244K	DO229045	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.1111
p.D255N	DO229058	LICA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.6932
p.P254S	DO230550	LUSC	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.5641
p.P243S	DO37406	SKCM	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.0833
p.P243L	DO50291	SKCM	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.0833
p.A251S	DO229253	THCA	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.3056
p.D255E	DO41235	UCEC	ICGC	LKPTPGGS	DEG_SCF_FBW7_1	0.6758
p.P254A	SIDM00177	Melanoma	GDSC	LKPTPGGS	DEG_SCF_FBW7_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXK0	Polyhomeotic-like protein 2	DEG_SCF_FBW7_1	252:259	LKPTPGGS	FBXW7	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons