DegronMD

Uniprot ID: Q8IXK0

Source protein: Polyhomeotic-like protein 2

Source gene: PHC2

Class: DEG_SPOP_SBC_1

Location: 8:12

E3 ligase: SPOP

DEGRON score: 0.9118

ASA_SCORE: 103.02

COIL: 0.9584

CONS_SCORE: 0.4361

DSS_SCORE: 0.6387

HELIX: 0.0298

FCONS_SCORE: 0.9851

RIG_SCORE: 0.6673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S11Y	TCGA-AG-A002	READ	TCGA	PHTSS	DEG_SPOP_SBC_1	0.712
p.S21N	TCGA-JY-A6FH	ESCA	TCGA	PHTSS	DEG_SPOP_SBC_1	0.0833
p.E2D	DO48389	BLCA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P5L	DO233823	GACA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.25
p.P5L	DO41758	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.25
p.P11Q	DO20102	KIRC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.7035
p.V7D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PHTSS	DEG_SPOP_SBC_1	0.3056
p.V7D	ACH-002256	Leukemia	CCLE	PHTSS	DEG_SPOP_SBC_1	0.3056
p.V7D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95402	Mediator of RNA polymerase II transcription subunit 26	DEG_SPOP_SBC_1	228:232	PHTSS	SPOP	0.9917	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	778:782	PHTSS	SPOP	0.9879	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	8:12	PHTSS	SPOP	0.9118	More...
Q9BQS2	Synaptotagmin-15	DEG_SPOP_SBC_1	111:115	PHTSS	SPOP	0.9607	More...
Q9BWK5	Cell cycle regulator of non-homologous end joining	DEG_SPOP_SBC_1	100:104	PHTSS	SPOP	0.9513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons