DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PHTSS
Uniprot ID:
Q9BWK5
Source protein:
Cell cycle regulator of non-homologous end joining
Source gene:
CYREN
Class:
DEG_SPOP_SBC_1
Location:
100:104
E3 ligase:
SPOP
DEGRON score:
0.9513
ASA_SCORE:
96.88
COIL:
0.958
CONS_SCORE:
0.3941
DSS_SCORE:
0.7703
HELIX:
0.0238
FCONS_SCORE:
0.6963
RIG_SCORE:
0.4801
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E109D
SIDM00683
Prostate Carcinoma
GDSC
PHTSS
DEG_SPOP_SBC_1
0.1944
p.E109D
LNCaP-Clone-FGC
prostate
COSMIC
PHTSS
DEG_SPOP_SBC_1
0.1944
p.E90G
COR-L311
lung
COSMIC
PHTSS
DEG_SPOP_SBC_1
0.0556
Drug responses associated with CYREN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PHTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95402
Mediator of RNA polymerase II transcription subunit 26
DEG_SPOP_SBC_1
228:232
PHTSS
SPOP
0.9917
More...
P56645
Period circadian protein homolog 3
DEG_SPOP_SBC_1
778:782
PHTSS
SPOP
0.9879
More...
Q8IXK0
Polyhomeotic-like protein 2
DEG_SPOP_SBC_1
8:12
PHTSS
SPOP
0.9118
More...
Q9BQS2
Synaptotagmin-15
DEG_SPOP_SBC_1
111:115
PHTSS
SPOP
0.9607
More...
Q9BWK5
Cell cycle regulator of non-homologous end joining
DEG_SPOP_SBC_1
100:104
PHTSS
SPOP
0.9513
More...