DegronMD

Uniprot ID: O95402

Source protein: Mediator of RNA polymerase II transcription subunit 26

Source gene: MED26

Class: DEG_SPOP_SBC_1

Location: 228:232

E3 ligase: SPOP

DEGRON score: 0.9917

ASA_SCORE: 85.88

COIL: 0.9564

CONS_SCORE: 0.6356

DSS_SCORE: 0.7356

HELIX: 0.0196

FCONS_SCORE: 1.1637

RIG_SCORE: 0.5821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P228L	TCGA-94-8490	LUSC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.7582
p.P228L	DO52021	LUSC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.7582
p.G219C	TCGA-CD-A4MI	STAD	TCGA	PHTSS	DEG_SPOP_SBC_1	0.0833
p.G219C	DO47717	STAD	ICGC	PHTSS	DEG_SPOP_SBC_1	0.0833
p.A225T	TCGA-CV-7242	HNSC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.25
p.A225T	DO14974	HNSC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.25
p.V226M	TCGA-FI-A2D0	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.2778
p.V226M	DO43891	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.2778
p.H229Q	DO229037	LICA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95402	Mediator of RNA polymerase II transcription subunit 26	DEG_SPOP_SBC_1	228:232	PHTSS	SPOP	0.9917	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	778:782	PHTSS	SPOP	0.9879	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	8:12	PHTSS	SPOP	0.9118	More...
Q9BQS2	Synaptotagmin-15	DEG_SPOP_SBC_1	111:115	PHTSS	SPOP	0.9607	More...
Q9BWK5	Cell cycle regulator of non-homologous end joining	DEG_SPOP_SBC_1	100:104	PHTSS	SPOP	0.9513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons