DegronMD

Uniprot ID: Q9BQS2

Source protein: Synaptotagmin-15

Source gene: SYT15

Class: DEG_SPOP_SBC_1

Location: 111:115

E3 ligase: SPOP

DEGRON score: 0.9607

ASA_SCORE: 80.38

COIL: 0.8976

CONS_SCORE: 0.3596

DSS_SCORE: 0.3578

HELIX: 0.0388

FCONS_SCORE: 1.0928

RIG_SCORE: 0.6684

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G116S	DO35116	PACA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.3056
p.G116C	DO229250	THCA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.3056
p.G116D	ACH-000930	Breast Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	0.3056
p.G117S	TCGA-A5-A1OF	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.2778
p.G117S	TCGA-DU-6392	LGG	TCGA	PHTSS	DEG_SPOP_SBC_1	0.2778
p.G117S	DO22237	LGG	ICGC	PHTSS	DEG_SPOP_SBC_1	0.2778
p.G117S	DO42568	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.2778
p.G117D	ACH-000315	Lymphoma	CCLE	PHTSS	DEG_SPOP_SBC_1	0.2778
p.G117D	ACH-000534	Lymphoma	CCLE	PHTSS	DEG_SPOP_SBC_1	0.2778
p.G117D	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.2778
p.R118Q	DO222427	BTCA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.25
p.G119E	TCGA-D3-A1QA	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	0.2222
p.G119E	TCGA-W3-AA1V	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	0.2222
p.G119E	DO47469	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	0.2222
p.G119E	DO51276	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	0.2222
p.A106T	TCGA-EE-A3AC	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	0.1944
p.A106T	DO37631	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1944
p.A121V	TCGA-DI-A1BU	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.1667
p.A121V	DO42023	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P105L	TCGA-SX-A7SP	KIRP	TCGA	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P105L	TCGA-WS-AB45	COAD	TCGA	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P105L	DO51734	COAD	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P105L	DO49790	KIRP	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P105L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P121S	DO50970	LICA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 25 of 48 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWK5	Cell cycle regulator of non-homologous end joining	DEG_SPOP_SBC_1	100:104	PHTSS	SPOP	0.9513	More...
O95402	Mediator of RNA polymerase II transcription subunit 26	DEG_SPOP_SBC_1	228:232	PHTSS	SPOP	0.9917	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	778:782	PHTSS	SPOP	0.9879	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	8:12	PHTSS	SPOP	0.9118	More...
Q9BQS2	Synaptotagmin-15	DEG_SPOP_SBC_1	111:115	PHTSS	SPOP	0.9607	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons