DegronMD - Q9BQS2(SYT15)

FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. {ECO:0000250}.

GO - Biological processes (BP): calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; vesicle-mediated transport [GO:0016192]

GO - Molecular function (MF): calcium-dependent phospholipid binding [GO:0005544]; calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]

GO - Cellular component (CC): exocytic vesicle [GO:0070382]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G116S	DO35116	PACA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.G116C	DO229250	THCA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.G116D	ACH-000930	Breast Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.G117S	TCGA-A5-A1OF	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117S	TCGA-DU-6392	LGG	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117S	DO22237	LGG	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117S	DO42568	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117D	ACH-000315	Lymphoma	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117D	ACH-000534	Lymphoma	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117D	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.R118Q	DO222427	BTCA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.25
p.G119E	TCGA-D3-A1QA	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G119E	TCGA-W3-AA1V	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G119E	DO47469	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G119E	DO51276	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.A106T	TCGA-EE-A3AC	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.A106T	DO37631	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.A121V	TCGA-DI-A1BU	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.A121V	DO42023	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.P105L	TCGA-SX-A7SP	KIRP	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667

Showing 1 to 20 of 48 entries

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Kaplan plot for SYT15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT15

UniProt ID: Q9BQS2

Entrez ID: 102724488

Protein name: Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT15 in