DegronMD - Q9BQS2(SYT15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P103S	TCGA-50-5072	LUAD	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.P103S	DO25967	LUAD	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.G117S	TCGA-A5-A1OF	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117S	TCGA-DU-6392	LGG	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117S	DO22237	LGG	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117S	DO42568	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.P103L	TCGA-AJ-A3EK	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.P103L	DO41584	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.P103L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.P103L	MFE-319	endometrium	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.C104F	TCGA-BC-A216	LIHC	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1389
p.C104F	DO22929	LIHC	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1389
p.G119E	TCGA-D3-A1QA	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G119E	TCGA-W3-AA1V	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G119E	DO47469	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G119E	DO51276	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.A121V	TCGA-DI-A1BU	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.A121V	DO42023	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.A106T	TCGA-EE-A3AC	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.A106T	DO37631	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.W101L	TCGA-GN-A265	SKCM	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.W101L	DO37491	SKCM	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.P105L	TCGA-SX-A7SP	KIRP	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.P105L	TCGA-WS-AB45	COAD	TCGA	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.P105L	DO51734	COAD	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.P105L	DO49790	KIRP	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.P105L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.D102H	DO227947	BRCA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0833
p.R118Q	DO222427	BTCA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.25
p.P121S	DO50970	LICA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1667
p.G116S	DO35116	PACA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.R101I	DO232224	PBCA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.G116C	DO229250	THCA	ICGC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.W101R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.W101R	ACH-000302	Endometrial/Uterine Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.W101R	ACH-000983	Leukemia	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.W101R	ACH-002800	Unknown	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.W101R	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.D102Y	ACH-000263	Leukemia	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0833
p.D102Y	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0833
p.G117D	ACH-000315	Lymphoma	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117D	ACH-000534	Lymphoma	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G117D	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.G116D	ACH-000930	Breast Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.M123V	ACH-000943	Colon/Colorectal Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.M123V	ACH-002105	Bone Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.M123V	RKO	large intestine	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.M123V	ES4	bone	COSMIC	PHTSS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT15

UniProt ID: Q9BQS2

Entrez ID: 102724488

Protein name: Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT15 in