DegronMD

Uniprot ID: P56645

Source protein: Period circadian protein homolog 3

Source gene: PER3

Class: DEG_SPOP_SBC_1

Location: 778:782

E3 ligase: SPOP

DEGRON score: 0.9879

ASA_SCORE: 80.3

COIL: 0.953

CONS_SCORE: 0.3555

DSS_SCORE: 0.5373

HELIX: 0.0188

FCONS_SCORE: 1.0256

RIG_SCORE: 0.5407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P769S	TCGA-4R-AA8I	LIHC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.0833
p.A788V	TCGA-BT-A3PJ	BLCA	TCGA	PHTSS	DEG_SPOP_SBC_1	0.1667
p.P772L	TCGA-HG-A9SC	CESC	TCGA	PHTSS	DEG_SPOP_SBC_1	0.1667
p.A771V	DO222955	BTCA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.1389
p.P780L	DO51603	CESC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.7582
p.P780S	DO222755	COCA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.6752
p.Q776H	DO228974	LICA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.2778
p.R768L	DO229015	LICA	ICGC	PHTSS	DEG_SPOP_SBC_1	0.0556
p.P777S	DO49657	LIHC	ICGC	PHTSS	DEG_SPOP_SBC_1	0.3056
p.Q773K	SIDM01690	Plasma Cell Myeloma	GDSC	PHTSS	DEG_SPOP_SBC_1	0.1944
p.Q773K	ACH-000453	Myeloma	CCLE	PHTSS	DEG_SPOP_SBC_1	0.1944
p.S781F	SIDM00217	Colorectal Carcinoma	GDSC	PHTSS	DEG_SPOP_SBC_1	0.7982
p.S781F	ACH-000999	Colon/Colorectal Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	0.7982
p.S781F	SNU-1040	large_intestine	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.7982
p.A782P	SIDM00363	Acute Myeloid Leukemia	GDSC	PHTSS	DEG_SPOP_SBC_1	0.7503
p.A782P	ACH-000770	Leukemia	CCLE	PHTSS	DEG_SPOP_SBC_1	0.7503
p.A782P	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.7503
p.H772R	ACH-002149	Ovarian Cancer	CCLE	PHTSS	DEG_SPOP_SBC_1	0.1667
p.A774P	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.2222
p.S773F	SNU-1040	large_intestine	COSMIC	PHTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95402	Mediator of RNA polymerase II transcription subunit 26	DEG_SPOP_SBC_1	228:232	PHTSS	SPOP	0.9917	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	778:782	PHTSS	SPOP	0.9879	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	8:12	PHTSS	SPOP	0.9118	More...
Q9BQS2	Synaptotagmin-15	DEG_SPOP_SBC_1	111:115	PHTSS	SPOP	0.9607	More...
Q9BWK5	Cell cycle regulator of non-homologous end joining	DEG_SPOP_SBC_1	100:104	PHTSS	SPOP	0.9513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons