DegronMD - O95402(MED26)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P228L	TCGA-94-8490	LUSC	TCGA	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.7582
p.P228L	DO52021	LUSC	ICGC	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.7582
p.W576C	TCGA-B5-A1MX	UCEC	TCGA	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667
p.W576C	DO41999	UCEC	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667
p.G219C	TCGA-CD-A4MI	STAD	TCGA	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.0833
p.G219C	DO47717	STAD	ICGC	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.0833
p.A225T	TCGA-CV-7242	HNSC	TCGA	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.25
p.A225T	DO14974	HNSC	ICGC	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.25
p.D588N	TCGA-DK-A3IL	BLCA	TCGA	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.3056
p.D588N	DO555	BLCA	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.3056
p.V226M	TCGA-FI-A2D0	UCEC	TCGA	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.2778
p.V226M	DO43891	UCEC	ICGC	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation rewiring degron network	0.2778
p.D583N	DO230334	COCA	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation altering degron motif	0.5821
p.N572K	DO228948	LICA	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.0556
p.P584Q	DO229019	LICA	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation altering degron motif	0.7035
p.H229Q	DO229037	LICA	ICGC	PHTSS	DEG_SPOP_SBC_1	228:232	Mutation altering degron motif	0.647
p.T577K	DO229041	LICA	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1944
p.R590H	DO29760	OV	ICGC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.25
p.I593V	SIDM00043	Head and Neck Carcinoma	GDSC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667
p.I593V	SIDM01149	Small Cell Lung Carcinoma	GDSC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667
p.I593V	SIDM00794	Other Solid Cancers	GDSC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667
p.I593V	SIDM00059	Ovarian Carcinoma	GDSC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667
p.I593V	SIDM01696	Mesothelioma	GDSC	LDPHGD	LIG_APCC_ABBA_1	582:587	Mutation rewiring degron network	0.1667

Kaplan plot for MED26 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED26

UniProt ID: O95402

Entrez ID: 9441

Protein name: Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED26 in